Effect of restricted protein diet supplemented with keto analogues in chronic kidney disease: a systematic review and meta-analysis

Abstract

Background

To evaluate the efficacy and safety of the restricted protein diet (low or very low protein diet) supplemented with keto analogues in the treatment of chronic kidney disease (CKD).

Methods

The Cochrane library, PubMed, Embase, CBM and CENTRAL databases were searched and reviewed up to April 2015. Clinical trials were analyzed using RevMan 5.3 software.

Results

Seven random control trials, one cross-over trial and one non-randomized concurrent control trial were selected and included in this study according to our inclusion and exclusion criteria. The changes of eGFR, BUN, Scr, albumin, PTH, triglyceride, cholesterol, calcium, phosphorus and nutrition indexes (BMI, lean body mass and mid-arm muscular circumference) before and after treatment were analyzed. The meta-analysis results indicated that, comparing with normal protein diet, low protein diet (LPD) or very low protein diet (vLPD) supplemented with keto analogues (s(v)LPD) could significantly prevent the deterioration of eGFR (P < 0.001), hyperparathyroidism (P = 0.04), hypertension (P < 0.01) and hyperphosphatemia (P < 0.001). No differences in BUN, Scr, Albumin, triglyceride, cholesterol, hemoglobin, calcium and nutrition indexes were observed between different protein intake groups.

Conclusion

Restricted protein diet supplemented with keto analogues (s(v)LPD) could delay the progression of CKD effectively without causing malnutrition.

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Correspondence to Wei Qin.

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On behalf of all authors, the corresponding author states that there is no conflict of interest.

Additional information

Zheng Jiang and Xiaoyan Zhang have contributed equally to this manuscript.

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Jiang, Z., Zhang, X., Yang, L. et al. Effect of restricted protein diet supplemented with keto analogues in chronic kidney disease: a systematic review and meta-analysis. Int Urol Nephrol 48, 409–418 (2016). https://doi.org/10.1007/s11255-015-1170-2

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Keywords

  • Restricted protein diet
  • Keto analogues
  • Chronic kidney disease
  • Meta-analysis
  • Systematic review