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Serum paraoxonase activity is associated with epicardial fat tissue in renal transplant recipients

  • Nephrology - Original Paper
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Abstract

Aims

Cardiovascular disease is a major cause of mortality in renal transplant recipients. Paraoxonase-1 (PON-1) has been shown to protect against atherosclerosis by modifying lipoproteins. Epicardial fat tissue (EFT) has been proposed as a new cardiovascular risk factor. The aim of this study was to investigate the relationship between PON-1 activity and EFT in renal transplant recipients.

Methods

Eighty renal transplant recipients were enrolled in this cross-sectional study. PON-1 activity was assessed from the rate of enzymatic hydrolysis of paraoxon to p-nitrophenol. EFT was measured by echocardiography.

Results

The mean age of the patients was 40.4 ± 12.3 years and mean post transplant follow-up duration was 57.2 ± 46 months. Mean PON-1 activity was 68.5 ± 30 U/L. PON-1 activity was positively correlated with age and body mass index and negatively correlated with parathyroid hormone, dialysis duration and EFT. The mean EFT thickness was 0.64 ± 0.17 cm. Multiple linear regression analysis was used to define independent determinants of EFT in renal transplant recipients. According to linear regression analysis, PON-1 levels and age were found to be independent predictors of EFT.

Conclusion

Reduced PON-1 activity was negatively associated with EFT and PON-1 activity independently predicts EFT in renal transplant recipients.

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Authors and Affiliations

  1. Department of Internal Medicine, Erciyes University Medical School, Kayseri, Turkey

    Eray Eroglu & Hafsa Korkar

  2. Department of Nephrology, Erciyes University Medical School, Kayseri, Turkey

    Ismail Kocyigit, Aydin Unal, Murat Hayri Sipahioglu, Bulent Tokgoz & Oktay Oymak

  3. Department of Biochemistry, Kayseri Training and Research Hospital, Kayseri, Turkey

    Cigdem Karakukcu

  4. Department of Cardiology, Erciyes University Medical School, Kayseri, Turkey

    Ozcan Orscelik

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  1. Eray Eroglu
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Correspondence to Eray Eroglu.

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Eroglu, E., Kocyigit, I., Unal, A. et al. Serum paraoxonase activity is associated with epicardial fat tissue in renal transplant recipients. Int Urol Nephrol 47, 1409–1414 (2015). https://doi.org/10.1007/s11255-015-1051-8

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  • DOI: https://doi.org/10.1007/s11255-015-1051-8

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