Abstract
Objective
Aging population has been increasing worldwide. So the number of elderly patients presenting with kidney disease has also been increasing. In this retrospective study, we assessed biopsy results of elderly patients and their clinical presentations.
Materials and methods
Native renal biopsy results of 98 elderly patients (≥65 years) were analyzed. These 98 patients consisted of 56 males (57.1 %) and 42 females (42.9 %) with a mean age of 70.59 ± 5.31 years (65–88 years).
Results
The clinical presentations of our elderly patients were nephritic syndrome (n = 45), acute kidney injury (n = 35), nephrotic syndrome (n = 33), chronic kidney disease (n = 32) and combined nephritic and nephrotic syndrome (n = 14). In patients with nephritic syndrome, the most common diagnosis was crescentic GN (17.8 % type 3 and 13.3 % types 1 and 2). Crescentic GN was also the most frequent among patients with acute kidney injury (37.1 %), while membranous nephropathy was the major histopathological diagnosis in chronic kidney disease patients. In nephrotic syndrome, the most common histopathological diagnosis was AA amyloidosis. None of the patients had a major life-threatening complication.
Conclusion
Biopsies in the elderly are as safe as in the general population. Renal biopsy should be performed to provide an accurate diagnosis and initiate specific treatment in elderly patients.
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References
World Population Aging, US National Institute on Aging (2015). http://www.nia.nih.gov/research/dbsr/world-population-aging
Aslan D (2013) Aged population is increasing in turkey: situation analysis. Acta Med 2:23–25
Nair R, Bell JM, Walker PD (2004) Renal biopsy in patients aged 80 years and older. Am J Kidney Dis 44(4):618–626
Parrish AE (1992) Complications of percutaneous renal biopsy: a review of 37 years’ experience. Clin Nephrol 38(3):135–141
Kohli HS, Jairam A, Bhat A, Sud K, Jha V, Gupta KL, Sakhuja V (2006) Safety of kidney biopsy in elderly: a prospective study. Int Urol Nephrol 38(3–4):815–820. doi:10.1007/s11255-006-0088-0
Haas M, Spargo BH, Wit EJ, Meehan SM (2000) Etiologies and outcome of acute renal insufficiency in older adults: a renal biopsy study of 259 cases. Am J Kidney Dis 35(3):433–447
Abrass CK (1985) Glomerulonephritis in the elderly. Am J Nephrol 5(6):409–418
Rao PS, Merion RM, Ashby VB, Port FK, Wolfe RA, Kayler LK (2007) Renal transplantation in elderly patients older than 70 years of age: results from the Scientific Registry of Transplant Recipients. Transplantation 83(8):1069–1074. doi:10.1097/01.tp.0000259621.56861.31
Tuglular S, Yalcinkaya F, Paydas S, Oner A, Utas C, Bozfakioglu S, Ataman R, Akpolat T, Ok E, Sen S, Dusunsel R, Evrenkaya R, Akoglu E (2002) A retrospective analysis for aetiology and clinical findings of 287 secondary amyloidosis cases in Turkey. Nephrol Dial Transplant 17(11):2003–2005
Moutzouris DA, Herlitz L, Appel GB, Markowitz GS, Freudenthal B, Radhakrishnan J, D’Agati VD (2009) Renal biopsy in the very elderly. Clin J Am Soc Nephrol 4(6):1073–1082. doi:10.2215/CJN.00990209
Ferro G, Dattolo P, Nigrelli S, Michelassi S, Pizzarelli F (2006) Clinical pathological correlates of renal biopsy in elderly patients. Clin Nephrol 65(4):243–247
Rivera F, Lopez-Gomez JM, Perez-Garcia R, Spanish Registry of G (2004) Clinicopathologic correlations of renal pathology in Spain. Kidney Int 66(3):898–904. doi:10.1111/j.1523-1755.2004.00833.x
Verde E, Quiroga B, Rivera F, Lopez-Gomez JM (2012) Renal biopsy in very elderly patients: data from the Spanish Registry of Glomerulonephritis. Am J Nephrol 35(3):230–237. doi:10.1159/000336307
Vendemia F, Gesualdo L, Schena FP, D’Amico G, Renal Immunopathology Study Group of the Italian Society of N (2001) Epidemiology of primary glomerulonephritis in the elderly. Report from the Italian Registry of Renal Biopsy. J Nephrol 14(5):340–352
Modesto-Segonds A, Ah-Soune MF, Durand D, Suc JM (1993) Renal biopsy in the elderly. Am J Nephrol 13(1):27–34
Cameron JS (1996) Nephrotic syndrome in the elderly. Semin Nephrol 16(4):319–329
Glassock RJ (1998) Glomerular disease in the elderly population. Geriatr Nephrol Urol 8(3):149–154
Peters B, Andersson Y, Stegmayr B, Molne J, Jensen G, Dahlberg P, Holm-Gunnarsson I, Ekberg J, Bjurstrom K, Haux SB, Hadimeri H (2014) A study of clinical complications and risk factors in 1,001 native and transplant kidney biopsies in Sweden. Acta Radiol 55(7):890–896. doi:10.1177/0284185113506190
Demircin G, Delibas A, Bek K, Erdogan O, Bulbul M, Baysun S, Oksal A, Memis L, Oner A (2009) A one-center experience with pediatric percutaneous renal biopsy and histopathology in Ankara, Turkey. Int Urol Nephrol 41(4):933–939. doi:10.1007/s11255-008-9433-9
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Harmankaya, O., Okuturlar, Y., Kocoglu, H. et al. Renal biopsy in the elderly: a single-center experience. Int Urol Nephrol 47, 1397–1401 (2015). https://doi.org/10.1007/s11255-015-1035-8
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DOI: https://doi.org/10.1007/s11255-015-1035-8