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The impact of female gender on bladder cancer-specific death risk after radical cystectomy: a meta-analysis of 27,912 patients

  • Urology - Original Paper
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Abstract

Objective

To perform a first meta-analysis on the association between female gender and cancer-specific death risk after radical cystectomy.

Materials and methods

A comprehensive literature search of the MEDLINE and EMBASE databases was conducted for relevant studies published till November 11, 2014. The meta-analysis was performed by estimating the hazard ratios (HRs) and confidence intervals (CIs) through a random-effect approach.

Results

A total of 17 studies were included in the meta-analysis with a total population of 27,912 patients. Female gender was associated with a worse survival outcome (pooled HR 1.20; 95 % CI 1.09–1.32) compared with male gender after radical cystectomy. Subgroup analysis found the correlation was significant in North American and European studies (HR 1.17, 95 % CI 1.02–1.32 and HR 1.34, 95 % CI 1.19–1.51, respectively) and studies from larger size of samples (HR 1.24, 95 % CI 1.11–1.38). We also found studies adjusted for the key elements (T stage, N stage and grade) obtained positive correlation (HR 1.21, 95 % CI 1.09–1.35).

Conclusions

Female demonstrated worse survival outcomes than male after radical cystectomy for bladder cancer. The adoption of more intense cares for female patients was suggested after radical cystectomy.

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Acknowledgments

We thank all the study participants, urologists and study coordinators for participating in the study. The study was supported by National Natural Science Foundation of China (Grant No. 81272853).

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standard

The meta-analysis study protocol was approved by the Ethics Committee of Huashan Hospital, Fudan University.

Author information

Authors and Affiliations

  1. Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China

    Shenghua Liu, Tian Yang, Rong Na, Mengbo Hu, Limin Zhang, Haowen Jiang & Qiang Ding

  2. Department of Urology, Huashan Hospital, Fudan University, 12 Wulumuqi Rd (M), Shanghai, 200040, China

    Shenghua Liu, Tian Yang, Rong Na, Mengbo Hu, Limin Zhang, Haowen Jiang & Qiang Ding

  3. Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China

    You Fu

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  1. Shenghua Liu
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  2. Tian Yang
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  4. Mengbo Hu
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  5. Limin Zhang
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Correspondence to Haowen Jiang or Qiang Ding.

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Liu, S., Yang, T., Na, R. et al. The impact of female gender on bladder cancer-specific death risk after radical cystectomy: a meta-analysis of 27,912 patients. Int Urol Nephrol 47, 951–958 (2015). https://doi.org/10.1007/s11255-015-0980-6

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  • DOI: https://doi.org/10.1007/s11255-015-0980-6

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