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The association of ApE1 −656T>G and 1349T>G polymorphisms and idiopathic male infertility risk

  • Urology - Original Paper
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Abstract

Purpose

In spite of variety studies in understanding of human reproductive and fertility, the underlying causes of male infertility remains undefined in about 50 % of cases. The polymorphism studies have a crucial role in diseases recognizing. Human apurinic/apyrimidinic endonuclease 1 (ApE1) is a multifunctional protein that has an important role in the base excision repair pathway. The present study was aimed to evaluate whether two polymorphisms −656T>G and 1349T>G ApE1 are related with the susceptibility to idiopathic male infertility.

Methods

Samples were collected from 180 patients diagnosed with idiopathic male infertility and 120 control subjects and genotyped by tetra-primer amplification refractory mutation system PCR.

Results

We observed a significant difference in genotype distributions of −656T>G ApE1 polymorphism between infertile patients and controls (P = 0.0001). Our findings indicated individuals with the variant TG genotypes had a significant increased risk of idiopathic male infertility (OR 1.84, 95 % CI 1.09–3.11, P = 0.021), whereas the significant association between the 1349T>G polymorphism and idiopathic male infertility risk was not observed (P = 0.2).

Conclusions

Our data suggest that the −656T>G ApE1 polymorphism may be associated with increased risk of idiopathic male infertility. Larger studies with more patients and controls are needed to confirm the results.

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Acknowledgments

We are especially grateful to all the experts who were integral partner in the preparation of facilities. This study was supported financially by the University of Guilan.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standard

All procedures were performed in concord with the Declaration of Helsinki regarding the use of human samples.

Author information

Authors and Affiliations

  1. Department of Biology, Faculty of Sciences, University of Guilan, P.O. Box 1914, Rasht, Iran

    Mostafa Yousefi, Zivar Salehi & Farhad Mashayekhi

  2. Cellular and Molecular Research Center, Faculty of Medical Sciences, Guilan University of Medical Sciences, Rasht, Iran

    Mohammad Hadi Bahadori

Authors
  1. Mostafa Yousefi
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  2. Zivar Salehi
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  3. Farhad Mashayekhi
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  4. Mohammad Hadi Bahadori
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Corresponding author

Correspondence to Zivar Salehi.

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Cite this article

Yousefi, M., Salehi, Z., Mashayekhi, F. et al. The association of ApE1 −656T>G and 1349T>G polymorphisms and idiopathic male infertility risk. Int Urol Nephrol 47, 921–926 (2015). https://doi.org/10.1007/s11255-015-0979-z

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  • DOI: https://doi.org/10.1007/s11255-015-0979-z

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