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The comparison of GLUT-4 and nNOS expression in diabetic and non-diabetic patients with BPH/LUTS

  • Urology - Original Paper
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Abstract

Purpose

The aim of this study was to compare glucose transporter-4 (GLUT-4) and neuronal nitric oxide synthase (nNOS) expression in diabetic and non-diabetic patients who underwent TUR-P or transvesical prostatectomy with the diagnosis of BPH.

Methods

Thirty diabetic patients with an average age of 58 and 30 non-diabetic patients with that of 56 were included in the study. T-PSA, IPSS, Q max value and prostate volume were compared between the two groups. The stromal and glandular staining scores of GLUT-4 and nNOS expression were compared. Student’s t test and Mann–Whitney U test were used for statistical analysis.

Results

There was no statistically significant difference in terms of age, IPSS, Qmax and PSA. Patients with diabetes had larger prostate volumes (p = 0.02). Mean GLUT-4 glandular total scores in diabetic and non-diabetic patients were 3.36 ± 1.21 and 2.1 ± 1.39, respectively, whereas stromal total scores were 3.63 ± 1.12 and 2.46 ± 1.33, and they were both statistically significant (p = 0.028 and p = 0.032, respectively). Glandular total nNOS scores in diabetic and non-diabetic patients were 4.53 ± 1.0 and 2.80 ± 1.12, while stromal total scores were 1.76 ± 1,0 and 2.30 ± 1.08 and they were found to be statistically significant (p = 0.0001 and p = 0.037, respectively).

Conclusions

GLUT-4 expression was found higher in prostatic tissue of the patients with diabetes mellitus. The expression value of nNOS was higher in the glandular area in diabetic patients, while stromal area expression score was higher in non-diabetic patients. Although our findings indicate important results, carefully designed further studies are needed to better comprehend the role of GLUT-4 and NOS pathways in BPH/LUTS pathophysiology.

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Authors and Affiliations

  1. Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey

    Alper Otunctemur & Huseyin Besiroglu

  2. Department of Urology, Bahcelievler State Hospital, Istanbul, Turkey

    Murat Dursun

  3. Department of Urology, Derince Training and Research Hospital, Kocaeli, Turkey

    Levent Ozcan

  4. Department of Urology, Medipol University, Istanbul, Turkey

    Emre Can Polat

  5. Department of Pathology, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey

    Adnan Somay & Nurver Ozbay

  6. Department of Urology, Katip Celebi University Atatürk Training and Research Hospital, Izmir, Turkey

    Kutan Ozer & Emin Ozbek

Authors
  1. Alper Otunctemur
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  2. Huseyin Besiroglu
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  3. Murat Dursun
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  4. Levent Ozcan
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  5. Emre Can Polat
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  6. Adnan Somay
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  7. Nurver Ozbay
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  8. Kutan Ozer
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  9. Emin Ozbek
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Correspondence to Huseyin Besiroglu.

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Otunctemur, A., Besiroglu, H., Dursun, M. et al. The comparison of GLUT-4 and nNOS expression in diabetic and non-diabetic patients with BPH/LUTS. Int Urol Nephrol 47, 899–904 (2015). https://doi.org/10.1007/s11255-015-0964-6

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  • DOI: https://doi.org/10.1007/s11255-015-0964-6

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