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Nationwide renal biopsy data in Lithuania 1994–2012

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Abstract

Background

Our aim was to evaluate the incidence of biopsy-proven kidney diseases in Lithuania and to compare their changes in three different time intervals. All Lithuanian kidney biopsies were performed in the National Center of Pathology, enabling analysis at the national level.

Methods

The native kidney biopsy data were reviewed, and incidence of renal disorders and patient demographics were compared during three time intervals: 1994–1999, 2000–2006, and 2007–2012.

Results

A total of 5,368 kidney biopsies were performed, including 3,640 native kidney and 1,728 kidney transplant biopsies; 59.5 % (2,165) of the native kidney biopsies were classified as primary glomerulopathies. The most common entity was IgA nephropathy (737; 34.0 %), followed by focal segmental glomerulosclerosis (285; 13.2 %) and membranoproliferative glomerulonephritis (256; 11.8 %). Prominent decrease in incidence of membranoproliferative glomerulonephritis (16.8 to 8.7 % from the first to third time interval) and increase in (mainly, pauci-immune) crescentic glomerulonephritis (6.2 to 15.3 %) were noted over the study period. In a subgroup of 427 pediatric native kidney biopsies, IgAN accounted for 24.9 % of biopsies. The incidence of MCNS increased dramatically from the first to third time interval (6.3 to 25.4 %), while the number of MPGN increased in the second time interval (from 7.2 to 8.9 %) but decreased in the third one (to 4.4 %).

Conclusions

Decrease in relative incidence of membranoproliferative glomerulonephritis, most likely, reflects improvement in socioeconomic conditions, while relative increase in crescentic glomerulonephritis is interpreted as improved diagnostics of the disease.

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Abbreviations

DPGN:

Diffuse endocapillary proliferative glomerulonephritis

FSGS:

Focal segmental glomerulosclerosis

GN:

Glomerulonephritis

HUS/TTP:

Hemolytic uraemic syndrome/thrombotic thrombocytopenic purpura

IgAN:

Immunoglobulin A nephropathy

MCNS:

Minimal change nephrotic syndrome

MN:

Membranous nephropathy

MPGN:

Membranoproliferative glomerulonephritis

NCP:

National Center of Pathology

NOS:

Not otherwise specified

Crescentic GN:

Crescentic glomerulonephritis

TA/IF:

Tubular atrophy/interstitial fibrosis

TMA:

Thrombotic microangiopathy

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Acknowledgments

The authors acknowledge National Center of Pathology and its renal pathology team for great collaboration.

Conflict of interest

The authors declare that they have no conflict of interests.

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Authors and Affiliations

  1. Faculty of Medicine, Vilnius University, Vilnius, Lithuania

    Ernesta Brazdziute, Marius Miglinas, Augustina Jankauskienė, Rimante Cerkauskiene & Arvydas Laurinavicius

  2. Nephrology Centre, Vilnius University Hospital “Santariskiu Klinikos”, Santariskiu str. 2, 08661, Vilnius, Lithuania

    Ernesta Brazdziute & Marius Miglinas

  3. Vilnius City Clinical Hospital, Vilnius, Lithuania

    Elita Gruodyte

  4. Klaipeda Seamen Hospital, Klaipeda, Lithuania

    Janina Priluckiene

  5. Republican Siauliu Hospital, Siauliai, Lithuania

    Algirdas Tamosaitis

  6. Faculty of Medicine, Nephrology Department, Lithuanian University of Health Sciences, Kaunas, Lithuania

    Inga Arune Bumblyte, Vytautas Kuzminskis & Birute Pundziene

  7. Affiliate of Vilnius Clinical Hospital, Vilnius, Lithuania

    Soneta Burbaickaja

  8. Governmental Hospital of Panevezys, Panevezys, Lithuania

    Marija Sakalauskienė

  9. Children Hospital Affiliate of Vilnius University Hospital “Santariskiu Klinikos”, Vilnius, Lithuania

    Augustina Jankauskienė & Rimante Cerkauskiene

  10. National Center of Pathology, Affiliate of Vilnius University Hospital “Santariskiu Klinikos”, Vilnius, Lithuania

    Arvydas Laurinavicius

Authors
  1. Ernesta Brazdziute
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  2. Marius Miglinas
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  3. Elita Gruodyte
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  4. Janina Priluckiene
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  5. Algirdas Tamosaitis
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  9. Marija Sakalauskienė
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  10. Augustina Jankauskienė
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  12. Birute Pundziene
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  13. Arvydas Laurinavicius
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Corresponding author

Correspondence to Ernesta Brazdziute.

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Brazdziute, E., Miglinas, M., Gruodyte, E. et al. Nationwide renal biopsy data in Lithuania 1994–2012. Int Urol Nephrol 47, 655–662 (2015). https://doi.org/10.1007/s11255-015-0927-y

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  • DOI: https://doi.org/10.1007/s11255-015-0927-y

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