International Urology and Nephrology

, Volume 47, Issue 4, pp 655–662 | Cite as

Nationwide renal biopsy data in Lithuania 1994–2012

  • Ernesta Brazdziute
  • Marius Miglinas
  • Elita Gruodyte
  • Janina Priluckiene
  • Algirdas Tamosaitis
  • Inga Arune Bumblyte
  • Vytautas Kuzminskis
  • Soneta Burbaickaja
  • Marija Sakalauskienė
  • Augustina Jankauskienė
  • Rimante Cerkauskiene
  • Birute Pundziene
  • Arvydas Laurinavicius
Nephrology - Original Paper

Abstract

Background

Our aim was to evaluate the incidence of biopsy-proven kidney diseases in Lithuania and to compare their changes in three different time intervals. All Lithuanian kidney biopsies were performed in the National Center of Pathology, enabling analysis at the national level.

Methods

The native kidney biopsy data were reviewed, and incidence of renal disorders and patient demographics were compared during three time intervals: 1994–1999, 2000–2006, and 2007–2012.

Results

A total of 5,368 kidney biopsies were performed, including 3,640 native kidney and 1,728 kidney transplant biopsies; 59.5 % (2,165) of the native kidney biopsies were classified as primary glomerulopathies. The most common entity was IgA nephropathy (737; 34.0 %), followed by focal segmental glomerulosclerosis (285; 13.2 %) and membranoproliferative glomerulonephritis (256; 11.8 %). Prominent decrease in incidence of membranoproliferative glomerulonephritis (16.8 to 8.7 % from the first to third time interval) and increase in (mainly, pauci-immune) crescentic glomerulonephritis (6.2 to 15.3 %) were noted over the study period. In a subgroup of 427 pediatric native kidney biopsies, IgAN accounted for 24.9 % of biopsies. The incidence of MCNS increased dramatically from the first to third time interval (6.3 to 25.4 %), while the number of MPGN increased in the second time interval (from 7.2 to 8.9 %) but decreased in the third one (to 4.4 %).

Conclusions

Decrease in relative incidence of membranoproliferative glomerulonephritis, most likely, reflects improvement in socioeconomic conditions, while relative increase in crescentic glomerulonephritis is interpreted as improved diagnostics of the disease.

Keywords

Epidemiology Glomerulonephritis Kidney biopsy Renal pathology 

Abbreviations

DPGN

Diffuse endocapillary proliferative glomerulonephritis

FSGS

Focal segmental glomerulosclerosis

GN

Glomerulonephritis

HUS/TTP

Hemolytic uraemic syndrome/thrombotic thrombocytopenic purpura

IgAN

Immunoglobulin A nephropathy

MCNS

Minimal change nephrotic syndrome

MN

Membranous nephropathy

MPGN

Membranoproliferative glomerulonephritis

NCP

National Center of Pathology

NOS

Not otherwise specified

Crescentic GN

Crescentic glomerulonephritis

TA/IF

Tubular atrophy/interstitial fibrosis

TMA

Thrombotic microangiopathy

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Ernesta Brazdziute
    • 1
    • 2
  • Marius Miglinas
    • 1
    • 2
  • Elita Gruodyte
    • 3
  • Janina Priluckiene
    • 4
  • Algirdas Tamosaitis
    • 5
  • Inga Arune Bumblyte
    • 6
  • Vytautas Kuzminskis
    • 6
  • Soneta Burbaickaja
    • 7
  • Marija Sakalauskienė
    • 8
  • Augustina Jankauskienė
    • 1
    • 9
  • Rimante Cerkauskiene
    • 1
    • 9
  • Birute Pundziene
    • 6
  • Arvydas Laurinavicius
    • 1
    • 10
  1. 1.Faculty of MedicineVilnius UniversityVilniusLithuania
  2. 2.Nephrology CentreVilnius University Hospital “Santariskiu Klinikos”VilniusLithuania
  3. 3.Vilnius City Clinical HospitalVilniusLithuania
  4. 4.Klaipeda Seamen HospitalKlaipedaLithuania
  5. 5.Republican Siauliu HospitalSiauliaiLithuania
  6. 6.Faculty of Medicine, Nephrology DepartmentLithuanian University of Health SciencesKaunasLithuania
  7. 7.Affiliate of Vilnius Clinical HospitalVilniusLithuania
  8. 8.Governmental Hospital of PanevezysPanevezysLithuania
  9. 9.Children Hospital Affiliate of Vilnius University Hospital “Santariskiu Klinikos”VilniusLithuania
  10. 10.National Center of PathologyAffiliate of Vilnius University Hospital “Santariskiu Klinikos”VilniusLithuania

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