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Intradetrusor injection of adult muscle-derived cells for the treatment of underactive bladder: pilot study

  • Urology - Original Paper
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Abstract

We conducted the first-regenerative medicine cellular therapy for underactive bladder (UAB) in an FDA-approved, compassionate-use IND trial to evaluate treatment safety and potential clinical efficacy of autologous muscle-derived stem cells (AMDC) on a patient with UAB. No study-related adverse events or side effects were reported. In the 1-year follow-up period, the subject denied any gross hematuria, urgency, frequency or infection. A reduction in maximum cystometric capacity from 844 to 663 mL was observed, and the patient was able to void small amounts but continues to require self-catheterization 1 year after AMDC injection. Intradetrusor injection of AMDC is safe, minimally invasive and a promising treatment option for the UAB.

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Acknowledgments

The authors wish to thank the Robert B. and Ann S. Aikens Urology Research Fund for supporting UAB research.

Conflict of interest

Ryan Pruchnic is an employee of Cook Myosite. Michael B. Chancellor has financial interest and a consultant relationship with Cook Myosite. There are no other conflicts of interest related to this publication to report.

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Authors and Affiliations

  1. Department of Urology, Aikens Center of Neurourology Research, William Beaumont Hospital, Royal Oak, MI, USA

    Peter E. Levanovich, Ananias Diokno, Deborah L. Hasenau, Michelle Lajiness & Michael B. Chancellor

  2. Cook Myosite, Inc., Pittsburgh, PA, USA

    Ryan Pruchnic

Authors
  1. Peter E. Levanovich
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  2. Ananias Diokno
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  3. Deborah L. Hasenau
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  4. Michelle Lajiness
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  5. Ryan Pruchnic
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  6. Michael B. Chancellor
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Correspondence to Michael B. Chancellor.

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Levanovich, P.E., Diokno, A., Hasenau, D.L. et al. Intradetrusor injection of adult muscle-derived cells for the treatment of underactive bladder: pilot study. Int Urol Nephrol 47, 465–467 (2015). https://doi.org/10.1007/s11255-015-0924-1

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  • DOI: https://doi.org/10.1007/s11255-015-0924-1

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