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Advanced therapeutic directions to treat the underactive bladder

  • Urology - Original Paper
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Abstract

Muscarinic agonists are the most commonly used agents for treating the underactive bladder (UAB). However, because of the absence of pharmacologic specificity for bladder-only effects and possibly as a result of degenerative and other post-synaptic changes involving detrusor smooth muscle cells, they are simply not effective and side effects are common. If safe and effective therapy for UAB is made available, then most experts agree that the potential market would exceed industry expectations, just as antimuscarinic agents for overactive bladder did in the late 1990s. The pharmaceutical and biotechnology industries that have a pipeline to urology and women’s health should consider UAB as a potential target condition. A rational approach to treating the pathology of UAB is presented with a discussion of potential targets that may allow the development of safe and effective agents for the treatment of UAB.

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Acknowledgments

Funding for this conference was made possible (in part) by 1R13AG047010 from the National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the NIH; nor does mention by trade names, commercial practices, or organizations imply endorsement by the US Government.

Conflict of interest

Michael B Chancellor has conflicts of interest related to Allergan, Astellas, Cook, Lipella, Medtronic, Pfizer, and Targacept. There are no conflicts of interest for Phillip P. Smith, George A. Kuchel, Pradeep Tyagi, Subrata Pore, Christopher Chermansky, Naoki Yoshimura, and Peter Levanovich.

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Authors and Affiliations

  1. Department of Surgery, University of Connecticut Health Center, Farmington, CT, USA

    Phillip P. Smith

  2. UConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA

    Phillip P. Smith & George A. Kuchel

  3. Department of Urology, University of Pittsburgh, Pittsburgh, PA, USA

    Pradeep Tyagi, Subrata Pore, Christopher Chermansky & Naoki Yoshimura

  4. Department of Urology, William Beaumont Hospital, Royal Oak, MI, USA

    Michael Chancellor & Peter Levanovich

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Smith, P.P., Tyagi, P., Kuchel, G.A. et al. Advanced therapeutic directions to treat the underactive bladder. Int Urol Nephrol 46 (Suppl 1), 35–44 (2014). https://doi.org/10.1007/s11255-014-0809-8

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