Abstract
Objective
The objective of the study was to investigate whether prehypertension is associated with progression to chronic kidney disease (CKD) in the general population in central south China.
Methods
A prospective cohort study was carried out in 1,703 white-collar workers without preexisting CKD in Changsha in 2006 at baseline. The cohort population was followed for an average of 54 months by annual examinations. The glomerular filtration rate (GFR) was estimated using the Modification of Diet in Renal Disease study equation modified by the Chinese coefficient. CKD was defined as positive albuminuria or an estimated GFR <60 mL/min/1.73 m2. Blood pressure (BP) categories were defined by the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. The association of blood pressure and CKD incidence was examined using a Cox regression model adjusted for relevant factors.
Results
During the follow-up of cohort, 194 incidences of CKD were recorded. Compared with normotension group, the hazard ratios (95 % confidential intervals) for CKD were 1.25 (1.02–1.85) in prehypertension group, 1.62 (1.07–2.79) in undiagnosed hypertension group, and 1.98 (1.15–3.96) in diagnosed hypertension group. Kaplan–Meier curves showed there was a significant difference in the cumulative incidence of CKD between the different blood pressure categories (log-rank test, P < 0.001). The independent risk factors of CKD were age, estimated glomerular filtration rate (eGFR), systolic blood pressure, and diastolic blood pressure according to the Cox proportional hazard analysis. It was found that 2.4 % in participants with CKD incidences could be described as excessive incidence attributable to prehypertension.
Conclusion
Prehypertension is significantly associated with CKD in a Chinese urban population.
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References
Zhang XH, Lu ZL, Liu L (2008) Coronary heart disease in China. Heart 94:1126–1131
Chobanian AV, Bakris GL, Black HR et al (2003) The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 289:2560–2572
Vasan RS, Beiser A, Seshadri S et al (2002) Residual lifetime risk for developing hypertension in middle-aged women and men: the Framingham Heart Study. JAMA 287:1003–1010
Wang W, Lee ET, Fabsitz RR et al (2006) A longitudinal study of hypertension risk factors and their relation to cardiovascular disease: the Strong Heart Study. Hypertension 47:403–409
Knobler H, Abbasi F, Lamendola C et al (2011) Insulin resistance and cardiovascular disease risk factors in subjects with prehypertension. Diab Vasc Dis Res 8:43–46
Redwine KM, Acosta AA, Poffenbarger T et al (2012) Development of hypertension in adolescents with pre-hypertension. J Pediatr 160:98–103
Sarnak MJ, Levey AS, Schoolwerth AC et al (2003) Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Hypertension 42:1050–1065
Haroun MK, Jaar BG, Hoffman SC et al (2003) Risk factors for chronic kidney disease: a prospective study of 23,534 men and women in Washington County, Maryland. J Am Soc Nephrol 14:2934–2941
Schaeffner ES, Kurth T, Bowman TS et al (2008) Blood pressure measures and risk of chronic kidney disease in men. Nephrol Dial Transplant 23:1246–1251
Peralta CA, Norris KC, Li S et al (2012) Blood pressure components and end-stage renal disease in persons with chronic kidney disease: the Kidney Early Evaluation Program (KEEP). Arch Intern Med 172:41–47
Obermayr RP, Temml C, Knechtelsdorfer M et al (2008) Predictors of new-onset decline in kidney function in a general middle-european population. Nephrol Dial Transplant 23:1265–1273
Sabanayagam C, Shankar A, Lim SC et al (2011) Hypertension, hypertension control, and chronic kidney disease in a Malay population in Singapore. Asia Pac J Public Health 23:936–945
Koh H, Hayashi T, Sato KK et al (2011) Blood pressure components and risk for chronic kidney disease in middle-aged Japanese men: the Kansai Healthcare Study. Hypertens Res 34:536–541
Chen J, Gu D, Chen CS et al (2007) Association between the metabolic syndrome and chronic kidney disease in Chinese adults. Nephrol Dial Transplant 22:1100–1106
Kawamoto R, Kohara K, Tabara Y et al (2008) An association between metabolic syndrome and the estimated glomerular filtration rate. Intern Med 47:1399–1406
Jang SY, Kim IH, Ju EY et al (2010) Chronic kidney disease and metabolic syndrome in a general Korean population: the Third Korea National Health and Nutrition Examination Survey (KNHANES III) Study. J Public Health (Oxf) 32:538–546
Perloff D, Grim C, Flack J et al (1993) Human blood pressure determination by sphygmomanometry. Circulation 88:2460–2470
Ma YC, Zuo L, Chen JH et al (2006) Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol 17:2937–2944
Kashif W, Siddiqi N, Dincer AP et al (2003) Proteinuria: how to evaluate an important finding. Cleve Clin J Med 70:535–547
Rockhill B, Newman B, Weinberg C (1998) Use and misuse of population attributable fractions. Am J Public Health 88:15–19
Fischer MJ, Ho PM, McDermott K et al (2013) Chronic kidney disease is associated with adverse outcomes among elderly patients taking clopidogrel after hospitalization for acute coronary syndrome. BMC Nephrol 14:107
Hsu CY, McCulloch CE, Darbinian J et al (2005) Elevated blood pressure and risk of end-stage renal disease in subjects without baseline kidney disease. Arch Intern Med 165:923–928
Reynolds K, Gu D, Muntner P et al (2007) A population-based, prospective study of blood pressure and risk for end-stage renal disease in China. J Am Soc Nephrol 18:1928–1935
Crews DC, Plantinga LC, Miller ER 3rd et al (2010) Prevalence of chronic kidney disease in persons with undiagnosed or prehypertension in the United States. Hypertension 55:1102–1109
Yano Y, Fujimoto S, Sato Y et al (2012) Association between prehypertension and chronic kidney disease in the Japanese general population. Kidney Int 81:293–299
Kanno A, Kikuya M, Ohkubo T et al (2012) Pre-hypertension as a significant predictor of chronic kidney disease in a general population: the Ohasama Study. Nephrol Dial Transplant 27:3218–3223
Lin Y, Lai X, Chen G et al (2012) Prevalence and risk factors associated with prehypertension and hypertension in the Chinese She population. Kidney Blood Press Res 35:305–313
Li H, Xu T, Tong W et al (2008) Comparison of cardiovascular risk factors between prehypertension and hypertension in a Mongolian population, Inner Mongolia, China. Circ J 72:1666–1673
Sarnak MJ, Greene T, Wang X et al (2005) The effect of a lower target blood pressure on the progression of kidney disease: long-term follow-up of the modification of diet in renal disease study. Ann Intern Med 142:342–351
National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 39:S1–S266
Acknowledgments
This work was supported in part by a grant from Key Science and Technology Projects in Hunan Province (2011SK2012) and a grant from Science and Technology Plan Projects (2011BAI11B01).We thank Chang Liu for his help in programming and statistical analyses as well as all participants for their contribution.
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Cao, X., Xie, X., Zhou, J. et al. Relationship between prehypertension and incidence of chronic kidney disease in a general population: a prospective analysis in central south China. Int Urol Nephrol 46, 2183–2189 (2014). https://doi.org/10.1007/s11255-014-0805-z
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DOI: https://doi.org/10.1007/s11255-014-0805-z