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Association between non-alcoholic fatty liver disease and chronic kidney disease in population with prediabetes or diabetes

International Urology and Nephrology volume 46, pages 1785–1791 (2014)Cite this article

Abstract

Purpose

The relationship between chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD) in population with diabetes remains controversial. Our current study aimed to explore the association between NAFLD and CKD in population with prediabetes or diabetes.

Methods

A cross-sectional study was conducted in Zhuhai city from June to October 2012. A total of 190 out of 334 participants with prediabetes or diabetes were enrolled in this study. CKD was defined as estimated GFR <60 ml/min per 1.73 m2 and/or albumin-to-creatinine ratio ≥30 mg/g. NAFLD was diagnosed on the basis of ultrasonographic and excluded fatty liver disease caused by other reasons such as drinking. The association between NAFLD and CKD was then analyzed using SPSS (version 19.0).

Results

Subjects with NAFLD were more likely with a higher urinary albumin-to-creatinine ratio (P < 0.001). CKD were common among patients with NAFLD than those without NAFLD (P < 0.05). NAFLD was significantly associated with CKD (P < 0.05) in the unadjusted analyses as well as after adjustment for potential confounders. The unadjusted odd ratio and adjusted odd ratio for CKD were 2.25 (95 % CI 1.07–4.77, P = 0.034) and 2.68 (95 % CI 1.12–6.01, P = 0.016). When further adjusted for hypertension, serum high-density lipoprotein and serum fasting glucose, the association of NAFLD with CKD was still significant (OR 2.78, 95 % CI 1.03–7.52, P = 0.044).

Conclusions

Our current study suggests that ultrasound-diagnosed NAFLD is associated with CKD among population with prediabetes or diabetes.

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Acknowledgments

This study was supported by the following Science Foundation: (1) EU FP7 Program, UroSense, 2011; (2) Guangdong Provincial Science and Technique Program (No. 2011B031800386), 2011.

Conflict of interest

No potential conflict of interest relevant to this article was reported.

Author information

Affiliations

  1. Department of Nephronology, Institute of Nephronology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, China

    Yongqiang Li, Shuangshuang Zhu, Bin Li, Xiaofei Shao, Xinyu Liu, Aiqun Liu, Bifang Wu, Ying Zhang, Honglei Wang, Xiaohong Wang, Kangping Deng, Qin Liu, Min Huang & Hequn Zou

  2. Department of Ultrasound, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, China

    Hongmei Liu

  3. National Centre for Sensor Research/BioAnalytical Sciences, Dublin City University, Dublin 9, Ireland

    Harry Holthöfer

Authors
  1. Yongqiang Li
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  2. Shuangshuang Zhu
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  3. Bin Li
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  4. Xiaofei Shao
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  5. Xinyu Liu
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  8. Ying Zhang
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  9. Honglei Wang
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  11. Kangping Deng
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  12. Qin Liu
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  13. Min Huang
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  14. Hongmei Liu
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  15. Harry Holthöfer
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  16. Hequn Zou
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Corresponding authors

Correspondence to Yongqiang Li or Hequn Zou.

Additional information

Yongqiang Li and Shuangshuang Zhu have contributed equally to this work.

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Li, Y., Zhu, S., Li, B. et al. Association between non-alcoholic fatty liver disease and chronic kidney disease in population with prediabetes or diabetes. Int Urol Nephrol 46, 1785–1791 (2014). https://doi.org/10.1007/s11255-014-0796-9

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  • DOI: https://doi.org/10.1007/s11255-014-0796-9

Keywords

  • Non-alcoholic fatty liver disease
  • Chronic kidney disease
  • Prediabetes
  • Diabetes