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Effect of continuous positive airway pressure on serum cystatin C among obstructive sleep apnea syndrome patients

  • Nephrology - Original Paper
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Abstract

Purpose

The purpose of the present study was to evaluate the influence of continuous positive airway pressure (CPAP) on serum cystatin C, a novel biomarker of early renal impairment, among obstructive sleep apnea (OSA) patients.

Materials and methods

Newly diagnosed severe OSA patients who treated with CPAP for 3 months were enrolled from two sleep laboratories. Serum biomarkers of renal impairment, cystatin C, creatinine and estimated glomerular filtration rate (eGFR), were detected before and after CPAP treatment.

Results

A total of 39 severe OSA patients were enrolled, 29 (74.4 %) were male, and mean age was 51.2 ± 12.2 years. After CPAP treatment, there were no changes of creatinine and eGFR (77.80 ± 20.00 vs. 75.3 ± 16.60 and 98.69 ± 31.74 vs. 100.20 ± 28.30, all p > 0.05), but cystatin C declined significantly (0.87 ± 0.18 vs. 0.77 ± 0.21, p = 0.000).

Conclusion

CPAP can decrease cystatin C levels among severe OSA patients and may prevent the latent renal impairment.

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Acknowledgments

This work was supported by grant 2013-2-88 for Youth Research Fund from Fujian Provincial Health Bureau.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Respiratory Medicine, Zhongshan Hospital, Xiamen University, No. 201, Hubin Nan Road, Siming District, Xiamen, 361004, Fujian, People’s Republic of China

    Xiao-Bin Zhang, Xing-Tang Jiang & Hui-Qing Zeng

  2. Department of Respiratory Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, People’s Republic of China

    Qi-Chang Lin & Xiao Chen

Authors
  1. Xiao-Bin Zhang
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  2. Xing-Tang Jiang
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  3. Qi-Chang Lin
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  5. Hui-Qing Zeng
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Correspondence to Xiao-Bin Zhang.

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All authors contributed equally to this work.

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Zhang, XB., Jiang, XT., Lin, QC. et al. Effect of continuous positive airway pressure on serum cystatin C among obstructive sleep apnea syndrome patients. Int Urol Nephrol 46, 1997–2002 (2014). https://doi.org/10.1007/s11255-014-0779-x

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  • DOI: https://doi.org/10.1007/s11255-014-0779-x

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