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Peritoneal transport rate, systemic inflammation, and residual renal function determine peritoneal protein clearance in continuous ambulatory peritoneal dialysis patients

  • Nephrology - Original Paper
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Abstract

Background

Peritoneal protein clearance (Pcl) is related to the mortality of patients on continuous ambulatory peritoneal dialysis (CAPD) as well as technique failure. In this prospective observational study, we aimed to investigate factors associated with the level of Pcl.

Methods

We prospectively enrolled 344 prevalent CAPD patients. A standard peritoneal equilibrium test was conducted for each patient. Baseline demographics, biochemistry, and Pcl were recorded.

Results

The average Pcl of the patients was 97.40 ± 54.14 mL/day. Peritoneal transport level, serum high-sensitivity C-reactive protein (hsCRP), and residual glomerular filtration rate (rGFR) were independently related to Pcl. The standard β values were 0.53, 0.17, and −0.10, respectively. Moreover, compared with non-diabetic patients, diabetic patients had a non-significantly higher level of Pcl (104.90 ± 48.65 vs. 96.15 ± 54.97 mL/day; P = 0.06).

Conclusion

Continuous ambulatory peritoneal dialysis patients lose a high amount of protein through the peritoneum each day. The Pcl value is positively related to the level of peritoneal transport and hsCRP and negatively related to the rGFR.

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Conflict of interest

The authors have no financial conflicts of interest to declare.

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Authors and Affiliations

  1. Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, People’s Republic of China

    Yi Tang, Hui Zhong, Yongshu Diao, Min Qin & Xueli Zhou

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  1. Yi Tang
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  2. Hui Zhong
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  3. Yongshu Diao
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  4. Min Qin
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  5. Xueli Zhou
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Corresponding author

Correspondence to Hui Zhong.

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Tang, Y., Zhong, H., Diao, Y. et al. Peritoneal transport rate, systemic inflammation, and residual renal function determine peritoneal protein clearance in continuous ambulatory peritoneal dialysis patients. Int Urol Nephrol 46, 2215–2219 (2014). https://doi.org/10.1007/s11255-014-0744-8

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  • DOI: https://doi.org/10.1007/s11255-014-0744-8

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