Abstract
Membranoproliferative glomerulonephritis type II (MPGN II), also known as a dense deposit disease, is a chronic progressive kidney disease that often progresses to end-stage renal disease within 10 years. Most patients also have multiple subretinal white spots or drusen-like deposits that are histopathologically identical to the glomerular basement membrane deposits. The purpose is to determine ocular findings in a patient with MPGN II before and after renal transplantation and to correlate them with clinical characteristics related to transplantation and review of literature. We present a case of a 45-year-old female with MPGN II who developed bilateral serous retinal detachment and retinal hemorrhages in the left eye, which appeared 6 months after a renal transplant. Ocular complications in our case, with the exception on the retina, were present at the cornea and iris. Changes to the eyes were independent of the renal disease, because there was no recurrence of MPGN II on the renal graft.
References
Appel GB, Cook HT, Hageman G et al (2005) Membranoproliferative glomerulonephritis type II (dense deposit disease): an update. J Am Soc Nephrol 16:1392–1403. doi:10.1681/ASN.2005010078
Mathieson PW, Peters DK (1997) Lipodystrophy and MCGN type II: the clue to links between the adipocyte and the complement system. Nephrol Dial Transplant 12:1804–1806. doi:10.1093/ndt/12.9.1804
Duvall-Yound J, MacDonald MK, McKechnie NM (1989) Fundus changes in (type II) mesangiocapillary glomerulonephritis simulating drusen: a histopathological report. Br J Ophthalmol 73:297–302
Gass JDM, Slamovits TL, Fuller DG, Gieser RG, Lean JS (1992) Posterior chorioretinopathy and retinal detachment after organ transplantation. Arch Ophthalmol 110:1717–1722. doi:10.1001/archopht.1992.01080240057030
Ponticelli C, Glassock RJ (2010) Posttransplant recurrence of primary glomerulonephritis. Clin J Am Soc Nephrol 5:2363–2372. doi:10.2215/CJN.06720810
D’souza Y, Short CD, McLeod D, Bonshek RE (2008) Long-term follow-up of drusen-like lesions in patients with type II mesangiocapillary glomerulonephritis. Br J Ophthalmol 92:950–953. doi:10.1136/bjo.2007.130138
Leys A, Van Damme B, Verberckmoes R (1996) Ocular complications of type 2 membranoproliferative glomerulonephritis. Nephrol Dial Transplant 11:211–214
Acknowledgments
The authors thank Aleksandra Radosavljevic, Assistant Professor of Ophthalmology, School of Medicine, University of Belgrade, for providing technical assistance and valuable comments.
Conflict of interest
The authors have no financial or proprietary interests related to this manuscript.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Abazi, Z., Magarasevic, L., Sukalo, S. et al. Ocular complications after kidney transplantation: a case report and review of literature. Int Urol Nephrol 46, 665–668 (2014). https://doi.org/10.1007/s11255-013-0627-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11255-013-0627-4