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Association of inflammaging (inflammation + aging) with higher prevalence of OAB in elderly population

  • Urology - Original Paper
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Abstract

Introduction

Although epidemiology studies consistently report increased prevalence of overactive bladder (OAB) with age, an accurate deciphering of causative links between the two entities remains elusive. Studies on aged rodent bladder have so far yielded contradictory results on age-associated changes in muscarinic receptors, which highlight the challenge posed by species differences in understanding OAB pathology. We hypothesized that age-related biochemical changes in bladder leading to altered bladder function will be reflected in altered urinary proteome of elderly OAB patients.

Methods

Single time point urine specimens were obtained from 140 OAB patients in the age range of 25–90 years of either sex coming routinely to the urology clinics. Eight chemokines in urine were measured by MILLIPLEX MAP human cytokine/chemokine multiplex immunoassay and ELISA. Multivariate and univariate statistical analyses were done to determine association of age with urinary chemokines in OAB patients.

Results

In agreement with age-dependent higher prevalence of OAB, the logistic regression of the data also revealed the significant association of OAB symptoms with age [odds ratio (OR) 1.12; 95 % CI, (1.072, 1.187), p = 0.0001]. Univariate analysis of 8 urinary proteins revealed an age-associated elevation of NGF (nerve growth factor) in 137 out of 140 OAB patients [Pearson r = 0.274; 95 %CI (0.112–0.422); p = 0.001]. Modest correlation with age was also noted for MCP-1 (monocyte chemoattractant protein-1), which was detected in 115 OAB patients, and the remaining chemokines were undetectable in nearly two-third of OAB patients included in our cohort.

Conclusions

Based on our findings, we postulate that age-associated biochemical changes may accentuate the inflammation associated with OAB. Urinary NGF elevation in elderly OAB patients may be a homeostatic response to counter the senescence of bladder nerves and arrest the progression of OAB into detrusor hyperactivity with impaired contractility. Likewise, elevation of MCP-1 may be related to decreased muscle mass and increased content of adipose tissue in bladder of elderly OAB patients. Urinary NGF and MCP-1 can serve as surrogate markers for monitoring age-associated biochemical changes and the effect of therapeutic interventions in OAB patients.

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Acknowledgments

The study was partly supported by the Pfizer OAB-LUTS grant.

Conflict of interest

None of the authors have any fin interest in the organization supporting this research.

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Authors and Affiliations

  1. Department of Urology, University of Pittsburgh, Pittsburgh, PA, USA

    Pradeep Tyagi

  2. William Beaumont Hospital, Royal Oak, MI, USA

    Vikas Tyagi & Michael Chancellor

  3. Oakland University, Rochester, MI, USA

    Xianggui Qu

  4. Buddhist Tzu Chi General Hospital, Hualien, Taiwan

    Hsin-Tzu Lin & Hann-Chorng Kuo

  5. Department of Urology, Kaohsiung Chang Gang Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung, Taiwan

    Yao-Chi Chuang

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  1. Pradeep Tyagi
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Correspondence to Pradeep Tyagi.

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Tyagi, P., Tyagi, V., Qu, X. et al. Association of inflammaging (inflammation + aging) with higher prevalence of OAB in elderly population. Int Urol Nephrol 46, 871–877 (2014). https://doi.org/10.1007/s11255-013-0621-x

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  • DOI: https://doi.org/10.1007/s11255-013-0621-x

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