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Influence of the lysine on the calcium oxalate renal calculi

International Urology and Nephrology volume 46, pages 593–597 (2014)Cite this article

Abstract

Plasma levels and urinary excretions of amino acid lysine were estimated by high-performance liquid chromatography in 15 control subjects and 56 stone formers (SFs) with calcium oxalate (CaOX) urolithiasis. Data demonstrated clearly that there is a general tendency toward decreased lysine’s excretions in above 40 % of SFs. Moreover, it was found that DL-lysine, a normal physiological constituent of urine, acts at increased concentrations as a dissolving agent with respect to CaOX and CaOX calculi. The kinetics of dissolution of crystalline calcium oxalate calculi in physiological solutions containing DL-lysine at different concentrations is studied, using the change in the Archimedean weight of samples immersed in the solution. The possible effect of lysine as a natural regulator of CaOX supersaturation and crystallization in human urine is also discussed.

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  1. Department of Clinical Laboratory and Clinical Immunology, Medical University, 1431, Sofia, Bulgaria

    Stoyanka S. Atanassova

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  1. Stoyanka S. Atanassova
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Correspondence to Stoyanka S. Atanassova.

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Atanassova, S.S. Influence of the lysine on the calcium oxalate renal calculi. Int Urol Nephrol 46, 593–597 (2014). https://doi.org/10.1007/s11255-013-0532-x

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  • DOI: https://doi.org/10.1007/s11255-013-0532-x

Keywords

  • Calcium oxalate calculi
  • Lysine
  • Dissolution of crystalline
  • Urine supersaturation