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Influence of the lysine on the calcium oxalate renal calculi

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Abstract

Plasma levels and urinary excretions of amino acid lysine were estimated by high-performance liquid chromatography in 15 control subjects and 56 stone formers (SFs) with calcium oxalate (CaOX) urolithiasis. Data demonstrated clearly that there is a general tendency toward decreased lysine’s excretions in above 40 % of SFs. Moreover, it was found that DL-lysine, a normal physiological constituent of urine, acts at increased concentrations as a dissolving agent with respect to CaOX and CaOX calculi. The kinetics of dissolution of crystalline calcium oxalate calculi in physiological solutions containing DL-lysine at different concentrations is studied, using the change in the Archimedean weight of samples immersed in the solution. The possible effect of lysine as a natural regulator of CaOX supersaturation and crystallization in human urine is also discussed.

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Authors and Affiliations

  1. Department of Clinical Laboratory and Clinical Immunology, Medical University, 1431, Sofia, Bulgaria

    Stoyanka S. Atanassova

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  1. Stoyanka S. Atanassova
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Correspondence to Stoyanka S. Atanassova.

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Atanassova, S.S. Influence of the lysine on the calcium oxalate renal calculi. Int Urol Nephrol 46, 593–597 (2014). https://doi.org/10.1007/s11255-013-0532-x

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