International Urology and Nephrology

, Volume 45, Issue 6, pp 1577–1587 | Cite as

Epidemiologic data of adult native biopsy-proven renal diseases in Croatia

  • Ivica HorvaticEmail author
  • Miroslav Tisljar
  • Stela Bulimbasic
  • Borka Bozic
  • Danica Galesic Ljubanovic
  • Kresimir Galesic
Nephrology - Original Paper



There is a paucity of epidemiological data on biopsy-proven renal disease in Croatia. The purpose of this report is a review of clinical and histological data, over a period of 15 years, from the single biggest adult native renal biopsy center in Croatia.


This report includes data from 922 adult native renal biopsies in patients referred from the whole country and performed in our center from 1996 till February 2012. Data on age, gender, serum creatinine, urine sediment, 24-h proteinuria, clinical syndrome and histological diagnosis were collected and analyzed retrospectively. In all patients, light, immunofluorescence and electron microscopic analysis was performed.


The median age of the patients was 48 years (interquartile range 36–59 years), and the majority of patients were men (57.8 %). The most common indication for renal biopsy was nephrotic syndrome (40.3 %) followed by asymptomatic urinary abnormalities (31.7 %). The most common biopsy-proven renal disease in total was IgA glomerulonephritis (19.3 %), followed by focal segmental glomerulosclerosis (FSGS) (15.8 %) and membranous glomerulonephritis (9.2 %). In men, similar results were found, while in women, the most common were hereditary nephritis (13.4 %), FSGS (12.9 %) and connective tissue disease–related glomerular disorders (11.6 %).


The presented data are an important contribution to the better understanding of the epidemiology of biopsy-proven renal disease in Croatia and Europe throughout comparison with other registry data. This data should be the basis for the formation of Croatian Registry of Renal Biopsies.


Biopsy-proven renal disease Epidemiology Glomerulonephritis Renal biopsy Renal pathology Registry 



Anti-GBM glomerulonephritis


Amyloidosis and other renal diseases with organized deposits


Acute nephritic syndrome


Acute postinfectious glomerulonephritis


Acute tubular injury


Acute tubulointerstitial nephritis


Asymptomatic urinary abnormalities


Biopsy-proven renal disease


Chronic nephritic syndrome


Glomerulonephritis associated with connective tissue diseases


Chronic tubulointerstitial nephritis


Diabetic nephropathy and metabolic diseases


Dysgammaglobulinemia associated disorders


Estimated glomerular filtration rate


End stage renal disease


Focal segmental glomerulosclerosis




IgA glomerulonephritis


Hereditary nephritis


Minimal change disease


Membranous glomerulonephritis


Membranoproliferative glomerulonephritis




Nephrotic syndrome


Pauci-immune glomerulonephritis


Tubulointerstitial disease


Thrombotic microangiopathy



This study was funded by the Croatian Ministry of Science, Education and Sports, project number 198-0000000-0179 (KG) and 198-0000000-3355 (DGLJ).

Conflict of interest

My statement (on behalf of all the authors) is as follows: We state that the results presented in this paper have not been published previously in whole or part, except in abstract form. We do not have any conflict of interest. We have had no involvements that might raise the question of bias in the work reported or in the conclusions, implications, or opinions stated. Ivica Horvatic.

Supplementary material

11255_2013_397_MOESM1_ESM.pdf (186 kb)
Supplementary material 1 (PDF 186 kb)
11255_2013_397_MOESM2_ESM.pdf (146 kb)
Supplementary material 2 (PDF 146 kb)
11255_2013_397_MOESM3_ESM.pdf (260 kb)
Supplementary material 3 (PDF 260 kb)
11255_2013_397_MOESM4_ESM.pdf (72 kb)
Supplementary material 4 (PDF 71 kb)


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Ivica Horvatic
    • 1
    Email author
  • Miroslav Tisljar
    • 1
  • Stela Bulimbasic
    • 1
  • Borka Bozic
    • 1
  • Danica Galesic Ljubanovic
    • 2
  • Kresimir Galesic
    • 2
  1. 1.Dubrava University HospitalZagrebCroatia
  2. 2.School of Medicine, Dubrava University HospitalUniversity of ZagrebZagrebCroatia

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