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Oxidative stress in patients treated with continuous ambulatory peritoneal dialysis (CAPD) and the significant role of vitamin C and E supplementation

International Urology and Nephrology volume 45, pages 1137–1144 (2013)Cite this article

Abstract

Purpose

Chronic renal failure patients undergoing peritoneal dialysis (PD) are characterized by increased oxidative stress (OS), which is associated with enhanced cardiovascular risk. Moreover, oxidative stress also contributes to peritoneal membrane changes and ultrafiltration failure. The aim of this study was to evaluate OS in PD patients and the effect of treatment with ascorbic acid and α-tocopherol.

Methods

Plasma, erythrocyte, urine, and peritoneal effluent samples from 20 patients on PD were evaluated for glutathione peroxidase and superoxide dismutase activity, total antioxidant capacity (TAC) and malondialdehyde (MDA) levels, as well as protein carbonyl formation, before and after administration of vitamin C, alone or in combination with vitamin E, in comparison with 10 apparently healthy control individuals.

Results

All studied markers showed enhanced OS in the PD group, compared to controls. The supplementation of vitamin C and E resulted in improvements of all the OS markers, as indicated by increased erythrocyte antioxidant enzymes activity and TAC levels, as well as decreased MDA concentration and carbonyl compound formation.

Conclusions

The oral supplementation of antioxidant vitamins C and E, in combination, can lead to decreased OS, thus providing a useful and cost-effective therapeutic option in PD patients.

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Acknowledgments

The authors gratefully acknowledge the assistance of Mrs Revell-Kaltsa Amanda for reviewing and editing the manuscript.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Affiliations

  1. Laboratory of Physiology, Faculty of Medicine, University of Ioannina, 45110, Ioannina, Greece

    Georgios Boudouris, Ioannis I. Verginadis, Yannis V. Simos, Andreas Zouridakis, Spyridon Ch. Karkabounas & Angelos M. Evangelou

  2. 4th Department of Internal Medicine, Hippokration General Hospital, Thessaloniki, Greece

    Georgios Boudouris

  3. Renal Unit, General Hospital, 46300, Filiates, Greece

    Andreas Zouridakis

  4. Department of Maxillofacial Surgery, University Hospital of Ioannina, Ioannina, Greece

    Vasilios Ragos

Authors
  1. Georgios Boudouris
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  2. Ioannis I. Verginadis
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  3. Yannis V. Simos
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  4. Andreas Zouridakis
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  5. Vasilios Ragos
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  6. Spyridon Ch. Karkabounas
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  7. Angelos M. Evangelou
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Correspondence to Georgios Boudouris or Angelos M. Evangelou.

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Boudouris, G., Verginadis, I.I., Simos, Y.V. et al. Oxidative stress in patients treated with continuous ambulatory peritoneal dialysis (CAPD) and the significant role of vitamin C and E supplementation. Int Urol Nephrol 45, 1137–1144 (2013). https://doi.org/10.1007/s11255-012-0334-6

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  • DOI: https://doi.org/10.1007/s11255-012-0334-6

Keywords

  • Oxidative stress
  • Peritoneal dialysis
  • Antioxidants
  • Ascorbic acid
  • a-tocopherol