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Long-term alpha-blockers and anticholinergic combination treatment for men with lower urinary tract symptoms in real-life practice

  • Urology – Original Paper
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Abstract

Purpose

To analyze the treatment outcomes and clinical courses for men with lower urinary tract symptoms, after long-term treatment of alpha-blocker and anticholinergic combination in real-life practice.

Materials and methods

A total of 210 men, with lower urinary tract symptoms, had combination therapy for 3 months. Patients were reevaluated and were decided on an alpha-blocker single treatment or a combination therapy, according to the patient-reported outcome for 2 years. The patient responses in 2-year treatment were divided into 3 groups, which depended on clinical courses: 56 patients had an alpha-blocker single therapy after 3-month combination therapy (group I); 106 patients had a continuous alpha-blocker therapy with intermittent 3-month anticholinergic therapy (group II); 48 patients with continuous storage symptoms maintained a combination therapy (group III). Endpoints included 2-year changes in International Prostate Symptom Score (IPSS), Qmax, and residual volume.

Results

Group III had significantly increased IPSS total and subscores compared to that of the other groups in the baseline characteristics. IPSS total and subscores significantly decreased at 3 months and were maintained for 2 years in all groups. Increase in Qmax was significant in all the groups at 3 months, and its increase was still significant after 2 years. Residual urine volume increased in all the groups at 3 months, but changes at 2 years were not statistically significant.

Conclusions

After 3 months of alpha-blocker and anticholinergic combination treatment, 73.4 % of the patients still needed a combination therapy. Although only one patient developed acute urinary retention, voiding difficulty was common (13.3 %), after a combination treatment in the real-life practice.

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Authors and Affiliations

  1. Department of Urology, Seoul St. Mary’s Hospital, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-040, Korea

    Woong Jin Bae, Jang Ho Bae, Yong Sun Choi, Su Jin Kim, Hyuk Jin Cho, Sung Hoo Hong, Sae Woong Kim, Tae-Kon Hwang & Ji Youl Lee

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  1. Woong Jin Bae
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  2. Jang Ho Bae
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  3. Yong Sun Choi
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  4. Su Jin Kim
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  5. Hyuk Jin Cho
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  9. Ji Youl Lee
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Correspondence to Ji Youl Lee.

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Bae, W.J., Bae, J.H., Choi, Y.S. et al. Long-term alpha-blockers and anticholinergic combination treatment for men with lower urinary tract symptoms in real-life practice. Int Urol Nephrol 44, 1077–1084 (2012). https://doi.org/10.1007/s11255-012-0173-5

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  • DOI: https://doi.org/10.1007/s11255-012-0173-5

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