Skip to main content

Advertisement

Log in

Epidermal growth factor receptor mediates injury in rapidly progressive glomerular disease

  • Nephrology – Translational Section
  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. Bollee G, Flamant M, Schordan S et al (2011) Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med 17:1242–1250

    Article  PubMed  CAS  Google Scholar 

  2. Bach D, Hauser K, Grabensee B (1996) Long-term clinical course in acute crescentic glomerulonephritis. Int Urol Nephrol 28:439–453

    Article  PubMed  CAS  Google Scholar 

  3. Kain R, Exner M, Brandes R et al (2008) Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis. Nat Med 14:1088–1096

    Article  PubMed  CAS  Google Scholar 

  4. Yarden Y, Sliwkowski MX (2001) Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2:127–137

    Article  PubMed  CAS  Google Scholar 

  5. Citri A, Yarden Y (2006) EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol 7:505–516

    Article  PubMed  CAS  Google Scholar 

  6. Schlessinger J (2002) Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 110:669–672

    Article  PubMed  CAS  Google Scholar 

  7. Zeng F, Singh AB, Harris RC (2009) The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology. Exp Cell Res 315:602–610

    Article  PubMed  CAS  Google Scholar 

  8. Holbro T, Civenni G, Hynes NE (2003) The ErbB receptors and their role in cancer progression. Exp Cell Res 284:99–110

    Article  PubMed  CAS  Google Scholar 

  9. Avraham R, Yarden Y (2011) Feedback regulation of EGFR signalling: decision making by early and delayed loops. Nat Rev Mol Cell Biol 12:104–117

    Article  PubMed  CAS  Google Scholar 

  10. Harris R (2011) EGFR signaling in podocytes at the root of glomerular disease. Nat Med 17:1188–1189

    Article  PubMed  CAS  Google Scholar 

  11. Tada H, Sasada R, Kawaguchi Y et al (1999) Processing and juxtacrine activity of membrane-anchored betacellulin. J Cell Biochem 72:423–434

    Article  PubMed  CAS  Google Scholar 

  12. Inui S, Higashiyama S, Hashimoto K et al (1997) Possible role of coexpression of CD9 with membrane-anchored heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth. J Cell Physiol 171:291–298

    Article  PubMed  CAS  Google Scholar 

  13. Anklesaria P, Teixido J, Laiho M et al (1990) Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation. Proc Natl Acad Sci USA 87:3289–3293

    Article  PubMed  CAS  Google Scholar 

  14. Iwamoto R, Mekada E (2000) Heparin-binding EGF-like growth factor: a juxtacrine growth factor. Cytokine Growth Factor Rev 11:335–344

    Article  PubMed  CAS  Google Scholar 

  15. Singh AB, Sugimoto K, Dhawan P et al (2007) Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance. Am J Physiol Cell Physiol 293:C1660–C1668

    Article  PubMed  CAS  Google Scholar 

  16. Sakai M, Zhang M, Homma T et al (1997) Production of heparin binding epidermal growth factor-like growth factor in the early phase of regeneration after acute renal injury. Isolation and localization of bioactive molecules. J Clin Invest 99:2128–2138

    Article  PubMed  CAS  Google Scholar 

  17. Yoshizumi M, Kourembanas S, Temizer DH et al (1992) Tumor necrosis factor increases transcription of the heparin-binding epidermal growth factor-like growth factor gene in vascular endothelial cells. J Biol Chem 267:9467–9469

    PubMed  CAS  Google Scholar 

  18. Kume N, Gimbrone MA Jr (1994) Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells. J Clin Invest 93:907–911

    Article  PubMed  CAS  Google Scholar 

  19. Marikovsky M, Breuing K, Liu PY et al (1993) Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury. Proc Natl Acad Sci USA 90:3889–3893

    Article  PubMed  CAS  Google Scholar 

  20. Higashiyama S, Abraham JA, Miller J et al (1991) A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 251:936–939

    Article  PubMed  CAS  Google Scholar 

  21. Blotnick S, Peoples GE, Freeman MR et al (1994) T lymphocytes synthesize and export heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor, mitogens for vascular cells and fibroblasts: differential production and release by CD4+ and CD8+ T cells. Proc Natl Acad Sci USA 91:2890–2894

    Article  PubMed  CAS  Google Scholar 

  22. Feng L, Garcia GE, Yang Y et al (2000) Heparin-binding EGF-like growth factor contributes to reduced glomerular filtration rate during glomerulonephritis in rats. J Clin Invest 105:341–350

    Article  PubMed  CAS  Google Scholar 

  23. Khong TF, Fraser S, Katerelos M et al (2000) Inhibition of heparin-binding epidermal growth factor-like growth factor increases albuminuria in puromycin aminonucleoside nephrosis. Kidney Int 58:1098–1107

    Article  PubMed  CAS  Google Scholar 

  24. Polihronis M, Murphy BF, Pearse MJ et al (1996) Heparin-binding epidermal growth factor-like growth factor, an immediate-early gene for mesangial cells, is up-regulated in the Thy-1.1 model. Exp Nephrol 4:271–278

    PubMed  CAS  Google Scholar 

  25. Triantafyllopoulou A, Franzke CW, Seshan SV et al (2010) Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages. Proc Natl Acad Sci USA 107:3012–3017

    Article  PubMed  CAS  Google Scholar 

  26. Mitamura T, Higashiyama S, Taniguchi N et al (1995) Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity. J Biol Chem 270:1015–1019

    Article  PubMed  CAS  Google Scholar 

  27. Kunami N, Yotsumoto F, Ishitsuka K et al (2011) Antitumor effects of CRM197, a specific inhibitor of HB-EGF, in T-cell acute lymphoblastic leukemia. Anticancer Res 31:2483–2488

    PubMed  CAS  Google Scholar 

  28. Miyamoto S, Yagi H, Yotsumoto F et al (2006) Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy. Cancer Sci 97:341–347

    Article  PubMed  CAS  Google Scholar 

  29. Hamaoka M, Chinen I, Murata T et al (2010) Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding. J Biochem 148:55–69

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

PRM is funded by Sonderforschungsbereich (SFB) 854, project 1 and ME1365/7-1.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sabine Brandt.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brandt, S., Mertens, P.R. Epidermal growth factor receptor mediates injury in rapidly progressive glomerular disease. Int Urol Nephrol 44, 971–975 (2012). https://doi.org/10.1007/s11255-012-0159-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11255-012-0159-3

Keywords

Navigation