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Association of insulin resistance with arterial stiffness in nondiabetic peritoneal dialysis patients

  • Nephrology – Original Paper
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Abstract

Background

Insulin resistance is a risk factor for cardiovascular morbidity and mortality in the general and end-stage renal disease populations. In this study, we investigated the association between insulin resistance and arterial stiffness in nondiabetic peritoneal dialysis (PD) patients.

Methods

Fifty-three patients were enrolled. Patients were divided into 2 groups as homeostasis model assessment of insulin resistance (HOMA-IR) ≤2.97 (low) and >2.97 (high). Carotid–femoral pulse wave velocity (c-f PWV) analysis and intima-media thickness of the carotid artery were measured.

Results

Mean age was 46 ± 12 years and HOMA-IR was 2.97 ± 1.77 (0.77–8.88). Mean c-f PWV was 7.6 ± 1.7 m/s. HOMA-IR was positively correlated with age, body mass index, and c-f PWV and negatively with serum HDL cholesterol and parathormone. In linear regression analysis, age and mean arterial pressure were predictors for c-f PWV. When patients were divided into 2 groups according to median age as ≤49 and >50, mean arterial pressure, male gender, and age were predictors for c-f PWV in patients aged ≤49, whereas HOMA-IR was the only predictor for c-f PWV in patients aged >50 years.

Conclusion

Insulin resistance is an independent risk factor for arterial stiffness in PD patients older than 50 years. IR is not associated with carotid intima-media thickness.

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Acknowledgments

The authors would like to thank Dr. Evert Dorhout Mees for his critical review of the manuscript. This study was presented as a free communication in 13th Congress of International Society of Peritoneal Dialysis, 2010, Mexico City and received the ISPD travel grant award.

Conflicts of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Division of Nephrology, Ege University School of Medicine, 35100, Bornova, Izmir, Turkey

    Erhan Tatar, Meltem Sezis Demirci, Fatih Kircelli, Ozkan Gungor, Mehmet Nuri Turan, Ebru Sevinc Ok, Gulay Asci, Mehmet Ozkahya & Ercan Ok

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  1. Erhan Tatar
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Correspondence to Erhan Tatar.

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Tatar, E., Demirci, M.S., Kircelli, F. et al. Association of insulin resistance with arterial stiffness in nondiabetic peritoneal dialysis patients. Int Urol Nephrol 44, 255–262 (2012). https://doi.org/10.1007/s11255-011-9984-z

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  • DOI: https://doi.org/10.1007/s11255-011-9984-z

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