Benign prostate hyperplasia (BPH) has been treated with various types of electromagnetic radiation methods such as transurethral needle ablation (TUNA), interstitial laser therapy (ILC), holmium laser resection (HoLRP). In the present study, the effects of a noninvasive method based on the exposure of patients with BPH to a pulsative EM Field at radiofrequencies have been investigated.
Materials and methods
Twenty patients with BPH, aging 68–78 years old (y.o), were enrolled in the study. Patients were randomly divided into two groups: the treatment group (10 patients, 74.0 ± 5.7 y.o) treated with the α-blocker Alfusosin, 10 mg/24 h for at least 4 weeks, and the electromagnetic group (10 patients, 73.7 ± 6.3 y.o) exposed for 2 weeks in a very short wave duration, pulsed electromagnetic field at radiofrequencies generated by an ion magnetic inductor, for 30 min daily, 5 consecutive days per week. Patients of both groups were evaluated before and after drug and EMF treatment by values of total PSA and prostatic PSA fraction, acid phosphate, U/S estimation of prostate volume and urine residue, urodynamic estimation of urine flow rate, and International Prostate Symptom Score (IPSS).
There was a statistically significant decrease before and after treatment of IPSS (P < 0.02), U/S prostate volume (P < 0.05), and urine residue (P < 0.05), as well as of mean urine flow rate (P < 0.05) in patients of the electromagnetic group, in contrast to the treatment group who had only improved IPSS (P < 0.05). There was also a significant improvement in clinical symptoms in patients of the electromagnetic group. Follow-up of the patients of this group for one year revealed that results obtained by EMFs treatment are still remaining.
Pulsed electromagnetic field at radiofrequencies may benefit patients with benign prostate hyperplasia treated by a non-invasive method.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Tax calculation will be finalised during checkout.
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
Tax calculation will be finalised during checkout.
Foster KR, Repacholi MH (2004) Biological effects of radiofrequency fields; does modulation matter? Rad Res 162:219–225
Tofani S, Cintorino M, Barone D et al (2002) Increased mouse survival, tumor growth inhibition and decreased immunoreactive P53, after exposure to magnetic fields. Bioelectromagnetics 23:230–238
Stronati L, Testa A, Villani P et al (2004) Absence of genotoxicity in human blood cells exposed to 50 Hz magnetic fields as assessed by comet assay, chromosome aberration, micronucleus, and sister chromatid exchange analyses. Bioelectromagnetics 25:41–48
Karkabounas S, Havelas K, Kostoula OK et al (2006) Effects of low intensity static electromagnetic fields on leiomyosarcoma and smooth muscle cell lines. Hell J Nucl Med 9:167–172
Charles L, Loomis D, Shy C et al (2003) Electromagnetic fields, polychlorinated biphenyls, and prostate cancer mortality in electric utility workers. Am J Epidemiol 157:683–691
Sauer H, Hescheler J, Reis D et al (1977) DC electrical field-induced c-fos expression and growth stimulation in multicecellular prostate cancer spheroids. Br J Cancer 75:1481–1487
Islamov BI, Balabonova RN, Futnikov VA et al (2002) Effect of bioresonance therapy on antioxidant system in lymphocytes in patients with rheumatoid arthritis. Bull Exp Biol Med 134:248–250
Athanasiou A, Karkabounas S, Batistatou A et al (2007) The effect of pulsed electromagnetic fields on secondary skin wound healing. An experimental study. Bioelectromagnetics 28:362–368
Weintraub MI, Wolfe GI, Barohn RA et al (2003) Static magnetic field therapy for symptomatic diabetic neuropathy: A randomized double-blind, placebo-controlled trial. Arch Phys Med Rehabil 84:736–746
Ahmed M, Bell T, Lawrenxe WT et al (1997) Transurethral microwave thermotherapy (Prostatron version 2.5) compared with transurethral of the prostate for the treatment of benign prostatic hyperplasia a randomized, controlled, parallel study. Br J Urol 79:181–185
Anson KM, Seenivasagam K, Watson GM (1994) Visual laser ablation of the prostate. Urology 43:276
Bagley D, Erhard M (1995) Use of the holmium laser in the upper urinary tract. Tech Urol 1:25–30
Giannakopoulos X et al. (1996) Transurethral needle ablation (TUNA) of the prostate: preliminary results using the new generation TUNA III catheter on patients with symptomatic BPH controlled by a series of 50 patients using the TUNA II device. In: Abstracts of the XIIth Congress European Association of Urology, Paris, France, 1–4 September 1996
Gilling PJ, Cass CB, Cresswell MD et al (1996) Holmium laser resection of the prostate: preliminary results of a new method for the treatment of benign prostatic hyperplasia. Urology 47:48–51
Madersbacher S, Pycha A, Klingler CH et al (1999) The International Prostate Symptom score in both sexes: a urodynamics-based comparison. Neurourol Urodyn 18:173–182
Anninos P, Papadopoulos I, Kotini A et al (2003) Differential diagnosis of prostate lesions with the use of biomagnetic measurements and non-linear analysis. Urol Res 31:32–36
Bellofonte C, Vedruccio C, Tubolini P et al (2005) Non-invasive detection of prostate cancer by electromagnetic interaction. Eur Urol 47:29–37
Suss S (1997) Bioresonance therapy in the treatment of allergies. Every person has its own vibration pattern. Fortschr Med 115:16–18
Panagopoulos JD, Messini N, Karabarbounis A et al (2000) A mechanism for action of oscillating electric fields on cells. Biochem Biophys Res 272:634–640
Chiabrera B, Bianco B, Moggia E et al (1994) Interaction mechanism between electromagnetic fields and ion absorption: endogenous forces and collision frequency. Bioelectrochem Bioenergetics 35:33–37
Carafoli E (2004) The ambivalent nature of calcium signal. J Endocrinol Invest 27:134–136
Pessina GP, Aldimucci C, Palmi M et al (2001) Pulsed electromagnetic fields affect the intracellular calcium concentrations in human astrocytoma cells. Bioelectromagnetics 22:503–510
Ikehara T, Park KH, Yamagushi H et al (2002) Effects of time varying strong magnetic field on release of cytosolic free Ca2+ from intracellular stores in cultural bovine adrenal chromaffin cells. Bioelectromagnetics 23:505–515
Abeele FV, Skryma R, Shuba Y et al (2002) Bcl-2-dependent modulation of Ca2+ homeostasis and store operated channels in prostate cancer cells. Cancer Cell 1:169–179
Kramer G, Mittereyer D, Marbeger M (2007) Is benign prostate hyperplasia (BPH) an immune inflammatory disease? Eur Urol 51:1202–1216
Johnson MT, Waite LR, Nindl G (2004) Non-invasive treatment of inflammation using electromagnetic fields: current and emerging therapeutic potential. Biomed Sci Instr 40:469–474
Jorgensen WA, Frome BM, Wallach C (1994) Electrochemical therapy of pelvic pain: Effects of pulsed electromagnetic fields (PEMF) on tissue trauma. Eur J Surg Suppl 574:83–86
Mihajlovic-Madzarevic V, Pappas P (2005) Treatment of refractory seizures due to a benign mass present in the corpus callosum with an ion magnetic inductor: case report. Brain Tumor Pathol 22:93–95
We thank Dr. P. Pappas for his kind donation of the Ion Magnetic Inductor device and for his technical advices.
About this article
Cite this article
Giannakopoulos, X.K., Giotis, C., Karkabounas, S.C. et al. Effects of pulsed electromagnetic fields on benign prostate hyperplasia. Int Urol Nephrol 43, 955–960 (2011). https://doi.org/10.1007/s11255-011-9944-7
- Pulsed EMFs
- Prostate hyperplasia