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Conversion from conventional in-centre thrice-weekly haemodialysis to short daily home haemodialysis ameliorates uremia-associated clinical parameters

  • Nephrology – Original Paper
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Abstract

Background

Under physiological conditions, kidneys work continuously, 168 h/week. In contrast, patients with end-stage renal disease are usually dialysed only 12 h/week. Even if considered adequate by current Kt/V-based dose estimates, this unphysiological dose is associated with an unacceptable annual mortality rate of 10–20%. Increasing dialysis dose might ameliorate this mortality rate.

Design

Eleven patients were switched from their conventional haemodialysis (cHD, 3 × 4 h/week) to an intensified short daily home haemodialysis regimen (sdhHD, 6 × 3 h/week) and followed up for 12 months. Different parameters were evaluated before treatment conversion and quarterly during follow-up [i.e. dialysis efficacy, mean arterial pressure (MAP), antihypertensive drug score, haemoglobin, transferrin saturation, ferritin, dose of erythropoiesis-stimulating agents (ESA), iron requirement, parameters of nutrition (body weight, albumin, protein), C-reactive protein, calcium–phosphate product, alkaline phosphatase (AP), intact parathyroid hormone (iPTH) and amount of phosphate-binding pharmacotherapy].

Results

HD efficacy as assessed by cumulative blood volume increased after dialysis intensification (P < 0.01). The pre- and post-dialytic MAP declined during the study period (P < 0.0001), while antihypertensive drugs could be reduced (P = 0.02). Haemoglobin levels improved (P < 0.0001). Additionally, the need for ESAs fell under intensified sdhHD (P = 0.008). Nutritional status improved [albumin, P = 0.03; total serum protein, P = 0.02; ‘dry’ body weight (BW) and body mass index (BMI) (both P < 0.001)]. The calcium–phosphate product declined (P < 0.01), without changes in the dose of phosphate binders.

Conclusion

Conversion from conventional in-centre to short daily home HD leads to an improvement in numerous dialysis-associated metabolic variables and thus represents an attractive treatment modality for selected patients.

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Authors and Affiliations

  1. Department of Medicine/Division of Nephrology and Hypertension, Hanover Medical School, Carl-Neuberg-Strasse 1, 30625, Hanover, Germany

    Johan M. Lorenzen, Georg M. Eisenbach, Hermann Haller & Jan T. Kielstein

  2. Department of Molecular and Translational Therapeutic Strategies, Hanover Medical School, Hanover, Germany

    Johan M. Lorenzen & Thomas Thum

Authors
  1. Johan M. Lorenzen
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  2. Thomas Thum
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  3. Georg M. Eisenbach
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  4. Hermann Haller
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  5. Jan T. Kielstein
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Correspondence to Johan M. Lorenzen.

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Lorenzen, J.M., Thum, T., Eisenbach, G.M. et al. Conversion from conventional in-centre thrice-weekly haemodialysis to short daily home haemodialysis ameliorates uremia-associated clinical parameters. Int Urol Nephrol 44, 883–890 (2012). https://doi.org/10.1007/s11255-011-9918-9

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  • DOI: https://doi.org/10.1007/s11255-011-9918-9

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