Abstract
Objective
It has been shown that coenzyme Q10 (CoQ10) supplementation in men with idiopathic oligoasthenoteratozoospermia (OAT) results in improved semen parameters. In present study, we evaluated the effects of coenzyme CoQ10 supplementation on semen parameters and pregnancy rates in infertile men with idiopathic OAT.
Patients and methods
Two hundred and eighty-seven infertile men with idiopathic OAT were recruited in this study. These patients were treated with CoQ10 300 mg orally twice daily for 12 months. Two semen analyses and determination of resting levels of sex hormones were done in all participants. Patients were followed up for another 12 months after CoQ10 discontinuation.
Results
Mean sperm concentration, sperm progressive motility, and sperm with normal morphology improved significantly after 12-month CoQ10 therapy by 113.7, 104.8, and 78.9%, respectively (all Ps < 0.05). The overall pregnancy rate was 34.1% within a mean of 8.4 ± 4.7 months.
Conclusions
CoQ10 supplementation improves semen quality with beneficial effect on pregnancy rate.
Similar content being viewed by others
Abbreviations
- OAT:
-
Oligoasthenoteratozoospermia
- CoQ10 :
-
Coenzyme Q10
- LH:
-
Luteinizing hormone (LH)
- FSH:
-
Follicle-stimulating hormone
- PRL:
-
Prolactin
- TSH:
-
Thyroid-stimulating hormone
- WHO:
-
World Health Organization
- SOD:
-
Superoxide dismutase
- NBT:
-
Nitroblue tetrazolium
- hCG:
-
Human chorionic gonadotropin
- TEAEs:
-
Treatment emergent adverse events
References
World Health Organisation (2002) Current practices and controversies in assisted production. Geneva, Switzerland
Safarinejad MR (2008) Infertility among couples in a population-based study in Iran: prevalence and associated risk factors. Int J Androl 31:303–314
World Health Organization (1992) The influence of varicocele on parameters of fertility in a large group of men presenting to fertility clinics. Fertil Steril 57:1289
Dennerstein L, Morse C (1988) A review of psychological and social aspects of in vitro fertilization. J Psychosom Obstet Gynaecol 9:159–170
Miesel R, Jedrzejczac P, Sanocka D, Kurpisz MK (1997) Severe antioxidase deficiency in human semen samples with pathological spermiogram parameters. Andrologia 29:77–83
Safarinejad MR, Safarinejad S (2009) Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol 181:741–751
Nohl H, Gille L, Kozlou AV (1999) Critical aspects of the antioxidant function of coenzyme Q in biomembranes. BioFactors 9:155–161
Bhagavan HN, Chopra RK (2007) Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion 7S:S78–S88
Balercia G, Buldreghini E, Vignini A et al (2009) Coenzyme Q(10) treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial. Fertil Steril 91:1785–1792
Safarinejad MR (2009) Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. J Urol 182:237–248
Kumar R, Gautam G, Gupta NP (2006) Drug therapy for idiopathic male infertility: rationale versus evidence. J Urol 176:1307–1312
World Health Organization (1999) WHO laboratory manual for the examination of human semen and sperm–cervical mucus interaction, 4th edn. Cambridge University Press, New York
Kruger TF, Menkveld R, Stander FS et al (1986) Sperm morphologic features as a prognostic factor in in vitro fertilization. Fertil Steril 46:1118–1123
Ikematsu H, Nakamura K, Harashima S et al (2006) Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol 44:212–218
Safarinejad MR (2010) Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study. Andrologia 41:1–10
Zini A, Fischer MA, Mak V et al (2002) Catalase-like and superoxide dismutase-like activities in human seminal plasma. Urol Res 30:321–323
Yeung CH, De Geyter C, De Geyter M et al (1996) Production of reactive oxygen species by and hydrogen peroxide scavenging activity of spermatozoa in an IVF program. J Assist Reprod Genet 13:495–500
Mahdi AA, Bano F, Singh R et al (1999) Seminal plasma superoxide dismutase and catalase activities in infertile men. Med Sci Res 27:201–203
Mancini A, Milardi D, Conte G et al (2003) Coenzyme Q10: another biochemical alteration linked to infertility in varicocele patients? Metabolism 52:402–406
Iwasaki A, Gagnon C (1992) Formation of reactive oxygen species in spermatozoa of infertile patients. Fertil Steril 57:409–416
Ernster L, Forsmark-Andrée P (1993) Ubiquinol: an endogenous antioxidant in aerobic organisms. Clin Invest 71:S60–S65
Bliznakov EG (1999) Cardiovascular diseases, oxidative stress and antioxidants: the decisive role of coenzyme Q10. Cardiovasc Res 43:248–249
Balercia G, Mosca F, Mantero F et al (2004) Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril 81:93–98
Evers JL, de Haas HW, Land JA et al (1998) Treatment-independent pregnancy rate in patients with severe reproductive disorders. Hum Reprod 13:1206–1209
Said RM, Agarwal A, Sharma RK et al (2004) Human sperm superoxide anion generation and correlation with semen quality in patients with male infertility. Fertil Steril 82:871–874
Agarwal A, Gupta S, Sikka S (2006) The role of free radicals and antioxidants in reproduction. Curr Opin Obstet Gynecol 18:325–332
Serour GI (2002) Attitudes and cultural perspectives on infertility and its alleviation in the Middle East area. In: Vayena E, Rowe PJ, Griffin PD (eds) Current practices and controversies in assisted reproduction. World Health Organization, Geneva, pp 41–49
de Kok BC, Widdicombe S (2008) ‘I really tried’: management of normative issues in accounts of responses to infertility. Soc Sci Med 67:1083–1093
Acknowledgments
The authors wish to express their thanks to the couples for their cooperation during the entire period of the study. We thank Shiva Safarinejad, for providing technical help and secretariat for the study, and Saba Safarinejad, for her precious help in data retrieval. There was no funding.
Conflict of interest
I have no conflict of interest whether of a financial or other nature.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Safarinejad, M.R. The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study. Int Urol Nephrol 44, 689–700 (2012). https://doi.org/10.1007/s11255-011-0081-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11255-011-0081-0