International Urology and Nephrology

, Volume 44, Issue 3, pp 689–700 | Cite as

The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study

Urology - Original Paper

Abstract

Objective

It has been shown that coenzyme Q10 (CoQ10) supplementation in men with idiopathic oligoasthenoteratozoospermia (OAT) results in improved semen parameters. In present study, we evaluated the effects of coenzyme CoQ10 supplementation on semen parameters and pregnancy rates in infertile men with idiopathic OAT.

Patients and methods

Two hundred and eighty-seven infertile men with idiopathic OAT were recruited in this study. These patients were treated with CoQ10 300 mg orally twice daily for 12 months. Two semen analyses and determination of resting levels of sex hormones were done in all participants. Patients were followed up for another 12 months after CoQ10 discontinuation.

Results

Mean sperm concentration, sperm progressive motility, and sperm with normal morphology improved significantly after 12-month CoQ10 therapy by 113.7, 104.8, and 78.9%, respectively (all Ps < 0.05). The overall pregnancy rate was 34.1% within a mean of 8.4 ± 4.7 months.

Conclusions

CoQ10 supplementation improves semen quality with beneficial effect on pregnancy rate.

Keywords

CoQ10 Supplementation Pregnancy rate Male factor infertility Treatment Semen parameters 

Abbreviation

OAT

Oligoasthenoteratozoospermia

CoQ10

Coenzyme Q10

LH

Luteinizing hormone (LH)

FSH

Follicle-stimulating hormone

PRL

Prolactin

TSH

Thyroid-stimulating hormone

WHO

World Health Organization

SOD

Superoxide dismutase

NBT

Nitroblue tetrazolium

hCG

Human chorionic gonadotropin

TEAEs

Treatment emergent adverse events

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Copyright information

© Springer Science+Business Media, B.V. 2011

Authors and Affiliations

  1. 1.Clinical Center for Urological Disease Diagnosis, Private Clinic Specialized in Urological and Andrological GeneticsTehranIran

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