The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study
It has been shown that coenzyme Q10 (CoQ10) supplementation in men with idiopathic oligoasthenoteratozoospermia (OAT) results in improved semen parameters. In present study, we evaluated the effects of coenzyme CoQ10 supplementation on semen parameters and pregnancy rates in infertile men with idiopathic OAT.
Patients and methods
Two hundred and eighty-seven infertile men with idiopathic OAT were recruited in this study. These patients were treated with CoQ10 300 mg orally twice daily for 12 months. Two semen analyses and determination of resting levels of sex hormones were done in all participants. Patients were followed up for another 12 months after CoQ10 discontinuation.
Mean sperm concentration, sperm progressive motility, and sperm with normal morphology improved significantly after 12-month CoQ10 therapy by 113.7, 104.8, and 78.9%, respectively (all Ps < 0.05). The overall pregnancy rate was 34.1% within a mean of 8.4 ± 4.7 months.
CoQ10 supplementation improves semen quality with beneficial effect on pregnancy rate.
KeywordsCoQ10 Supplementation Pregnancy rate Male factor infertility Treatment Semen parameters
Luteinizing hormone (LH)
World Health Organization
Human chorionic gonadotropin
Treatment emergent adverse events
- 1.World Health Organisation (2002) Current practices and controversies in assisted production. Geneva, SwitzerlandGoogle Scholar
- 3.World Health Organization (1992) The influence of varicocele on parameters of fertility in a large group of men presenting to fertility clinics. Fertil Steril 57:1289Google Scholar
- 12.World Health Organization (1999) WHO laboratory manual for the examination of human semen and sperm–cervical mucus interaction, 4th edn. Cambridge University Press, New YorkGoogle Scholar
- 15.Safarinejad MR (2010) Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study. Andrologia 41:1–10Google Scholar
- 18.Mahdi AA, Bano F, Singh R et al (1999) Seminal plasma superoxide dismutase and catalase activities in infertile men. Med Sci Res 27:201–203Google Scholar
- 27.Serour GI (2002) Attitudes and cultural perspectives on infertility and its alleviation in the Middle East area. In: Vayena E, Rowe PJ, Griffin PD (eds) Current practices and controversies in assisted reproduction. World Health Organization, Geneva, pp 41–49Google Scholar