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Effect of intraprostatic epinephrine on intraoperative blood loss reduction during transurethral resection of the prostate

  • Urology - Original paper
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An Urology – Letter to the Editor to this article was published on 29 July 2012

Abstract

Objective

To determine whether the use of intraprostatic epinephrine during transurethral resection of the prostate reduces intraoperative blood loss.

Methods

A random, double-blind, prospective study was carried out on twenty-three patients that underwent transurethral resection of the prostate. Patients were divided into two groups: (1) group receiving intraoperative intraprostatic injection of epinephrine (thirteen patients) and (2) group receiving intraoperative intraprostatic injection of saline solution as placebo (ten patients). Blood loss was quantified with the following formula: irrigation solution hemoglobin × 1000/intraoperative presurgical serum hemoglobin. The variables analyzed were blood loss, resection time, presurgical prostate volume, and grams of resected tissue. Student´s t test and Pearson correlation were used for their analysis.

Results

There were thirteen patients in the epinephrine group and ten patients in the placebo group. Mean blood loss in the epinephrine group was significantly lower than in the placebo group (127.48 mL ± 77.0 mL vs. 336.63 ± 185.6 mL, 95% CI, 45–234, P < 0.001). There were no statistically significant differences in mean resected grams or mean resection time between the two groups. One patient in the epinephrine group presented with intraoperative hypertensive crisis (7.7%).

Conclusions

Intraprostatic epinephrine injection can be used to reduce blood loss during transurethral resection of the prostate in selected patients. Cardiovascular monitoring should be carried out during its application. Resection time and grams of resected tissue continue to be the most influential factors in relation to blood loss in patients undergoing this treatment modality.

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Authors and Affiliations

  1. Department of Urology, Hospital General de México, O.D. Dr. Balmis 148 Col. Doctores Del. Cuauhtémoc, México, DF, México

    Alejandro Lira-Dale, Miguel Maldonado-Ávila, José Fernando Gil-García, Enrique Hans Mues-Guizar, Rubén Nerubay-Toiber & Ivan Delgado-Enciso

  2. Department of Urology, Hospital General de Zona No. 1, IMSS, Colima, Col., México

    Jose Guzmán-Esquivel

  3. Research Department, School of Medicine, University 333, Col. Las Viboras, Cp. 28000, Colima, Col., México

    Ivan Delgado-Enciso

  4. Cataviña 3, Fracc. Cataviña Tijuana B.C., México, 22470, México

    Alejandro Lira-Dale

  5. Zaragoza 377, Centro, 28000, Colima, Col., México

    Jose Guzmán-Esquivel

Authors
  1. Alejandro Lira-Dale
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  2. Miguel Maldonado-Ávila
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  3. José Fernando Gil-García
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  4. Enrique Hans Mues-Guizar
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  5. Rubén Nerubay-Toiber
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  6. Jose Guzmán-Esquivel
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  7. Ivan Delgado-Enciso
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Corresponding author

Correspondence to Jose Guzmán-Esquivel.

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Lira-Dale, A., Maldonado-Ávila, M., Gil-García, J.F. et al. Effect of intraprostatic epinephrine on intraoperative blood loss reduction during transurethral resection of the prostate. Int Urol Nephrol 44, 365–369 (2012). https://doi.org/10.1007/s11255-011-0071-2

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  • DOI: https://doi.org/10.1007/s11255-011-0071-2

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