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Systemic mastocytosis presenting with acute oliguric renal failure: report of a case and review of the literature

  • Nephrology – Case Report
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Abstract

A 61-year old African-American woman presented with abdominal pain, tender splenomegaly, anemia, and renal insufficiency. Bone marrow biopsy demonstrated systemic mastocytosis. She was treated with mediator-specific therapy and imatinib, but her renal and hepatic function deteriorated and she required maintenance hemodialysis. Renal biopsy demonstrated interstitial infiltration with mast cells and acute tubular necrosis. Acute kidney injury in the setting of systemic mastocytosis and imatinib therapy is discussed.

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Authors and Affiliations

  1. Pasadena Nephrology Corporation, Pasadena, CA, USA

    Ann E. Moore

  2. Department of Pathology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA

    William H. Johnston & Aviv Hever

  3. Department of Nephrology, Kaiser Permanente Bellflower Medical Center, Bellflower, CA, USA

    Susy Peng

  4. Department of Nephrology, Kaiser Permanente Los Angeles Medical Center, 4700 Sunset Blvd., 2nd floor, Los Angeles, CA, 90027, USA

    Dean A. Kujubu

Authors
  1. Ann E. Moore
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  2. William H. Johnston
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  3. Aviv Hever
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  4. Susy Peng
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  5. Dean A. Kujubu
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Corresponding author

Correspondence to Dean A. Kujubu.

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Moore, A.E., Johnston, W.H., Hever, A. et al. Systemic mastocytosis presenting with acute oliguric renal failure: report of a case and review of the literature. Int Urol Nephrol 44, 639–642 (2012). https://doi.org/10.1007/s11255-010-9878-5

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  • DOI: https://doi.org/10.1007/s11255-010-9878-5

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