Abstract
Previous studies have shown that the presence of simple renal cysts was related to hypertension. However, the relationship between simple renal cysts and circadian blood pressure was not studied before. Our study population comprised of newly diagnosed patients with essential hypertension. Medical history, physical examination and office blood pressure measurements, laboratory analysis, ambulatory blood pressure measurements, renal ultrasonography, and 24-h urine specimens were collected. In total, the study included 190 patients (male/female ratio 77/113; mean age 50.3 ± 11.3). Overall, 127 (66.8%) patients were dippers and 92 (48.4%) had at least one simple renal cyst. Thirty-five patients had solitary cysts and 57 patients had multiple cysts. Cysts were bilateral in 47 of patients. Most of ambulatory blood pressure recordings were higher in patients with at least one simple cyst when compared to patients without cysts. In multivariate logistic regression analysis, serum uric acid (P: 0.047, OR: 1.287, CI: 1.011–1.658), lower creatinine clearance (P: 0.001, OR: 1.030, CI: 1.012–1.049), presence of diabetes (P: 0.029, OR: 2.451, CI: 1.094–5.491), and presence of at least one cyst in each kidney (P: 0.002, OR: 3.087, CI: 1.533–6.212) were found to be independently related to nocturnal non-dipping. In conclusion, the presence of simple renal cysts is related to higher ambulatory BP and is associated with non-dipping phenomenon in patients with essential hypertension.
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References
Al-Said J, O’Neill WC (2003) Reduced kidney size in patients with simple renal cysts. Kidney Int 64:1059–1064
Lüscher TF, Wanner C, Siegenthaler W et al (1986) Simple renal cyst and hypertension: cause or coincidence? Clin Nephrol 26:91–95
Pedersen JF, Emamian SA, Nielsen MB (1997) Significant association between simple renal cysts and arterial blood pressure. Br J Urol 79:688–691
Akinci D, Akhan O, Ozmen M et al (2005) Long-term results of single-session percutaneous drainage and ethanol sclerotherapy in simple renal cysts. Eur J Radiol 54:298–302
Chin HJ, Ro H, Lee HJ et al (2006) The clinical significances of simple renal cyst: is it related to hypertension or renal dysfunction? Kidney Int 70:1468–1473
Al-Said J, Brumback MA, Moghazi S et al (2004) Reduced renal function in patients with simple renal cysts. Kidney Int 65:2303–2308
Holmberg G (1992) Diagnostic aspects, functional significance and therapy of simple renal cysts: a clinical, radiologic and experimental study. Scand J Urol Nephrol Suppl 145:1–48
Pickering TG, Kario K (2001) Nocturnal non-dipping: what does it augur? Curr Opin Nephrol Hypertens 10:611–616
Verdecchia P, Schillaci G, Porcellati C (1991) Dippers versus non-dippers. J Hypertens Suppl 9:S42–S44
Pickering TG, Devereux RB (1987) Ambulatory monitoring of blood pressure as a predictor of cardiovascular risk. Am Heart J 114:925–928
Ravine D, Gibson RN, Walker RG et al (1994) Evaluation of ultrasonographic diagnostic criteria for autosomal dominant polycystic kidney disease 1. Lancet 343:824–827
Giannakopoulos X, Charalabopoulos K, Charalabopoulos A et al (2005) Giant simple renal cyst complicated with hypertension. Int J Clin Pract Suppl 147:69–71
Pedersen JF, Emamian SA, Nielsen MB (1993) Simple renal cyst: relations to age and arterial blood pressure. Br J Radiol 66:581–584
Verdecchia P, Porcellati C, Schillaci G et al (1994) Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension. Hypertension 24:793–801
Babka JC, Cohen MS, Sode J (1974) Solitary intrarenal cyst causing hypertension. N Engl J Med 291:343–344
Churchill D, Kimoff R, Pinsky M et al (1975) Solitary intrarenal cyst: correctable cause of hypertension. Urology 6:485–488
Hoard TD, O’Brien DP 3rd (1976) Simple renal cyst and high renin hypertension cured by cyst decompression. J Urol 115:326–327
Terada N, Ichioka K, Matsuta Y et al (2002) The natural history of simple renal cysts. J Urol 167:21–23
Dalton D, Neiman H, Grayhack JT (1986) The natural history of simple renal cysts: a preliminary study. J Urol 135:905–908
Grantham JJ (1991) Acquired cystic kidney disease. Kidney Int 40:143–152
Preisig PA, Franch HA (1995) Renal epithelial cell hyperplasia and hypertrophy. Semin Nephrol 15:327–340
Baert L, Steg A (1977) Is the diverticulum of the distal and collecting tubules a preliminary stage of the simple cyst in the adult? J Urol 118:707–710
Davidson MB, Vidt DG, Hoogwerf BJ et al (2005) Relation of diurnal blood pressure variation and triglyceride-to-high-density lipoprotein cholesterol ratio in patients without diabetes mellitus. Am J Cardiol 95:123–126
Nielsen FS, Rossing P, Bang LE et al (1995) On the mechanisms of blunted nocturnal decline in arterial blood pressure in NIDDM patients with diabetic nephropathy. Diabetes 44:783–789
Nakano S, Fukuda M, Hotta F et al (1998) Reversed circadian blood pressure rhythm is associated with occurrences of both fatal and nonfatal vascular events in NIDDM subjects. Diabetes 47:1501–1506
Afsar B, Elsurer R, Ozdemir FN et al (2008) Uric acid and nocturnal nondipping in hypertensive patients with normal renal function. J Nephrol 21:406–411
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Afsar, B., Afsar, R.E., Sen, S.T. et al. Simple renal cysts and circadian blood pressure: are they related to each other in patients with hypertension?. Int Urol Nephrol 43, 157–165 (2011). https://doi.org/10.1007/s11255-010-9734-7
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DOI: https://doi.org/10.1007/s11255-010-9734-7