Skip to main content
SpringerLink
Log in

Low-density lipoprotein (LDL) apheresis reduces atherogenic and oxidative markers in uremic patients with hyperlipidemia

  • Nephrology – Original Paper
  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Uremic patients with hyperlipidemia are classified at high atherogenic risk due to oxidative stress induced by regular hemodialysis process (hemoincompatibility) and a high level of oxidized low-density lipoprotein (ox-LDL). This study aimed to investigate whether LDL apheresis was capable of reducing oxidative and atherogenic markers in uremic patients with hyperlipidemia. We found that oxidative metabolites (methylquanidine, dityrosine, and ox-LDL) and atherogenic markers (lipoprotein (a), LDL, and LDL/HDL ratio) were significantly reduced (P < 0.05) after LDL apheresis. On the other hand, plasma total antioxidant status (TAS) was not influenced after LDL apheresis. Our results suggest that LDL apheresis reduces oxidative and atherogenic markers and do not influence plasma TAS in uremic patients with hyperlipidemia. This may lead to a decreased risk of atherosclerosis in these patients. However, supplementation of dietary proteins may be necessary because of the removal of some “useful” proteins (e.g., albumin and globulin) after LDL apheresis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Erlenkotter A, Eudres P, Nederlof B, Homig C, Vieuken J (2008) Score model for the evaluation of dialysis membrane hemocompatibility. Artif Organs 32:962–969

    Article  PubMed  Google Scholar 

  2. Optrny K Jr, Kurouzzecky A, Polauska K, Mares J, Tomsu M, Bowry SK, Vienken J (2006) Does an alteration of dialyzer design and geometry affect biocompatibility parameters? Hemodial Int 10:201–208

    Article  Google Scholar 

  3. Colli-Benuour EE, Kouidhi B, Dey M, Youues R, Bouaziz C, Achour A (2009) Cytotoxic effects exerted by polyarylsulfone dialyzer membrane depend on different sterilization processes. Int Urol Nephrol Oct 1 [Epub ahead of print]

  4. de Sa HM, Freitas LA, Alves VC, Garcao MF, Rosa MA, Marques AA (2000) Leukocyte, platelet and endothelial activation in patients with acute renal failure treated with intermittent hemodialysis. Am J Nephrol 21:264–273

    Google Scholar 

  5. Banche G, Allizond V, Ciacchino F, Mandras N, Roana J, Bonello F, Belardi P, Tullio V, Merlino C, Carlone N, Cuffini AM (2006) Effect of dialysis membrane biocompatibility on polymorphonuclear granulocyte activity in dialysis patients. Nephrol Dial Transplant 21:3532–3538

    Article  PubMed  CAS  Google Scholar 

  6. Ishigaki Y, Ogihara T, Gao J (2008) Impact of plasma oxidized low-density removal on atherosclerosis. Circulation 118:75–83

    Article  PubMed  CAS  Google Scholar 

  7. Raffaella S, Aldo P (1995) Effect of methylquanidine on rat blood pressure: role of endothelial nitric oxide synthase. Br J Pharm 115:510–514

    Google Scholar 

  8. Winterbourn CC, Parsons-Mair HN, Gebicki S (2004) Requirements for superoxide-dependant tyrosine hydroperoxide formation in peptides. Biochem J 381:241–248

    Article  PubMed  CAS  Google Scholar 

  9. Borberg H (2009) 26 years of LDL-apheresis: a review of experience. Transfus Apher Sci 41:49–59

    Article  PubMed  CAS  Google Scholar 

  10. Mehta PK, Baer J, Nell C, Sperling LS (2009) Low-density lipoprotein apheresis as a treatment option for hyperlipidemia. Curr Treat Options Cardiovasc Med 11:279–288

    Article  PubMed  Google Scholar 

  11. Kobayashi S (2008) Application of LDL-apheresis in nephrology. Clin Exp Nephrol 12:9–15

    Article  PubMed  CAS  Google Scholar 

  12. Schettler M, Wieland E, Methe H (1998) Activity of free radical scavenging enzymes in red cells and plasma of patients undergoing extracorporeal low-density lipoprotein apheresis. Artif Organs 22:123–128

    Article  PubMed  CAS  Google Scholar 

  13. Schettler V, Methe H, Staschinsky D (1999) Review: the oxidant/antioxidant balance during low density lipoprotein apheresis. Ther Apher 3:219–226

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Graduate Institute of Basic Medical Science, China Medical University, Taichung, 404, Taiwan

    Tung-Sheng Chen & Chih-Yang Huang

  2. Formosan Blood Purification Foundation, 50, Sec. 1, Bade Rd., Taipei, Taiwan

    Show-Yih Liou

  3. School of Medicine, China Medical University, Taichung, 404, Taiwan

    Hsi-Chin Wu

  4. Graduate Institute of Chinese Medical Science, China Medical University, Taichung, 404, Taiwan

    Fuu-Jen Tsai & Chih-Yang Huang

  5. Department of Pediatrics, Medical Research and Medical Genetics, China Medical University, Taichung, 404, Taiwan

    Fuu-Jen Tsai

  6. Department of Healthcare Administration, Asia University, Taichung, 413, Taiwan

    Chang-Hai Tsai

  7. Department of Health and Nutrition Biotechnology, Asia University, Taichung, 413, Taiwan

    Chih-Yang Huang

  8. Department of Biomedical Engineering, Chung Yuan Christian University, 200, Chung Pei Rd., Chung Li, 32023, Taiwan

    Yen-Lin Chang

Authors
  1. Tung-Sheng Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Show-Yih Liou
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hsi-Chin Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fuu-Jen Tsai
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Chang-Hai Tsai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Chih-Yang Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yen-Lin Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yen-Lin Chang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chen, TS., Liou, SY., Wu, HC. et al. Low-density lipoprotein (LDL) apheresis reduces atherogenic and oxidative markers in uremic patients with hyperlipidemia. Int Urol Nephrol 43, 471–474 (2011). https://doi.org/10.1007/s11255-010-9722-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11255-010-9722-y

Keywords

Search

Navigation