Abstract
Objective
The growth of solid tumors requires angiogenesis. Evidence indicates that mast cells (MCs) play an important role in tumor angiogenesis but results are not definitive. The aim of this study is to investigate the possible effects of angiogenesis and the presence of MCs on the prognosis of renal cell carcinoma (RCC).
Patients and methods
The study involved 40 patients with RCC (24 men and 16 women who were treated with radical nephrectomy between 1995 and 2006, at our institution. The routine mast cell tryptase staining method was used to assess the MCs in both normal tissue and tumoral tissue. The immunohistochemical staining for CD34 antigen was used for determination of microvessel density. The relation between MC count and tumor status such as tumor stage, size, grade, and other clinicopathologic parameters in RCC were evaluated in this study.
Results
We found no relationship between the number of MCs and patient age, sex, tumor stage, grade, size. No association was noted between angiogenesis and either patient sex or age, tumor size, stage, and grade. No statistically significant correlation was found between the number of MCs and microvessel density in RCC (P-value = 0.45) but the max value of MCs and MVD were in clear cell carcinoma.
Conclusions
The MC count was not associated with tumor status such as tumor stage, size, grade, and other clinicopathologic parameters, however, MCs may be related to tumor angiogenesis and acceleration of tumor growth in RCC and therefore need further evaluation in RCC.
Similar content being viewed by others
References
Kirkali Z, Tuzel E, Mungan MU (2001) Recent advances in kidney cancer and metastatic disease. BJU Int 88:818–824. doi:10.1046/j.1464-4096.2001.02442.x
Kirkali Z, Lekili M (2003) Renal cell carcinoma new prognostic factors? Curr Opin Urol 13:433–438
Nativ O, Sabo E, Reiss A, Wald M, Madjar S, Moskovitz B (1998) Clinical significance of tumor angiogenesis in patients with localized renal cell carcinoma. Urology 51:693–696. doi:10.1016/S0090-4295(98)00019-3
Dekel Y, Koren R, Kugel V, Livne PM, Gal R (2002) Significance of angiogenesis and microvascular invasion in renal cell carcinoma. Pathol Oncol Res 8:129–132
Craft PS, Harris AL (1994) Clinical prognostic significance of tumor angiogenesis. Ann Oncol 5:305–311
Fox SD (1997) Tumor angiogenesis and prognosis. Histopathology 30:294–301. doi:10.1046/j.1365-2559.1997.d01-606.x
Patard JJ, Tazi H, Bensalah K et al (2004) The changing evolution of renal tumours: a single center experience over a two decade period. Eur Urol 45:490–493. doi:10.1016/j.eururo.2003.12.015
Weidner N, Semple JP, Welch WR, Folkman J (1991) Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 324:1–8
Weidner N, Carroll PR, Flax J, Blumendfeld W, Folkman J (1993) Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol 143:401–409
Macchiarini P, Fontanini G, Hardin MJ, Squartini F, Angeletti CA (1992) Relation of neovascularization to metastasis of non-small lung cancer. Lancet 340:145–146. doi:10.1016/0140-6736(92)93217-B
Bochner BH, Cote RJ, Weidner N et al (1995) Angiogenesis in bladder cancer: relationship between microvessel density and tumor prognosis. J Natl Cancer Inst 87:1603–1612. doi:10.1093/jnci/87.21.1603
Yoshino S, Kato M, Okada K (1995) Prognostic significance of microvessel count in low stage renal cell carcinoma. Int J Urol 2:156–160. doi:10.1111/j.1442-2042.1995.tb00445.x
MacLennan GT, Bostwick DG (1995) Microvessel density in renal cell carcinoma. Lack of prognostic significance. Urology 46:27–30. doi:10.1016/S0090-4295(99)80153-8
Ribatti D, Crivellato E, Roccaro M, Ria R, Vacca A (2004) Mast cell contribution to angiogenesis related to tumor progression. Clin Exp Allergy 34:1660–1664. doi:10.1111/j.1365-2222.2004.02104.x
Kirkali Z, Yorukoglu K, Ozkara E, Kazimoglu H, Mungan U (2001) Proliferative activity, angiogenesis and nuclear morphometry in renal cell carcinoma. Int J Urol 8:697–703. doi:10.1046/j.1442-2042.2001.00405.x
Ozer E, Yorukoglu K, Kirkali Z (2001) Tumor angiogenesis in superficial bladder cancer. Urol Integr Invest 6:70–78
Ehara T, Shigematsu H (2003) Mast cells in kidney. Nephrology 8:130–138. doi:10.1046/j.1440-1797.2003.00153.x
Slaton JW, Inoue K, Perrotte P et al (2001) Expression levels of genes that regulate metastasis and angiogenesis correlate with advanced pathological stage of renal cell carcinoma. Am J Pathol 158:735–743
Tuna B, Yorukoglu K, Unlu M, Mun (2006) Association of mast cells with microvessel density in renal cell carcinomas. Eur Urol 50(3):530–534. doi:10.1016/j.eururo.2005.12.040
Yildiz E, Ayan S, Goze F, Gokce G, Gultekin EY (2008) Relation of microvessel density with microvascular invasion, metastasis and prognosis in renal cell carcinoma. BJU Int 101(6):758–764. doi:10.1111/j.1464-410X.2007.07318.x
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mohseni, M.G., Mohammadi, A., Heshmat, A.S. et al. The lack of correlation between mast cells and microvessel density with pathologic feature of renal cell carcinoma. Int Urol Nephrol 42, 109–112 (2010). https://doi.org/10.1007/s11255-009-9577-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11255-009-9577-2