Skip to main content

Advertisement

SpringerLink
Log in

Quality of life in hemodialysis patients: hepatitis C virus infection makes sense

  • Nephrology - Original Paper
  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Purpose

Hepatitis C virus (HCV) infection impairs quality of life (QOL) in patients who are not on dialysis therapy. In dialysis patients, how HCV infection affects QOL is unknown. In our study, we investigated the independent relationship between HCV infection and QOL.

Methods

Sociodemographic and laboratory variables were recorded. Severity of depressive symptoms and QOL were assessed by Beck Depression Inventory (BDI) and Short Form-36 (SF-36), respectively.

Results

Among 165 patients, 83 were anti-HCV antibody positive and 82 were anti-HCV antibody negative. Anti-HCV antibody positive patients had higher BDI scores than anti-HCV antibody negative patients (P = 0.011). Other than the social functioning subscale, all SF-36 subscales were lower in anti-HCV antibody positive patients when compared with anti-HCV negative patients. Anti-HCV antibody positive patients had lower physical (P = 0.003) and mental component summary scores (P = 0.018) than negative patients. Physical component summary score was independently associated with hemodialysis duration (P = 0.003), sleep disturbance (P = 0.046), BDI score (P = 0.027), albumin (P = 0.002), and serum hemoglobin (P < 0.0001). Physical component summary score was not associated with anti-HCV antibody positivity. Mental component summary score was independently associated with BDI score (P = 0.001), anti-HCV antibody positivity (P = 0.016), and serum hemoglobin (P < 0.0001).

Conclusion

HCV infection impairs QOL, especially in mental aspects, in hemodialysis patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Manns BJ, Johnson JA, Taub K et al (2002) Dialysis adequacy and health related quality of life in hemodialysis patients. ASAIO J 48:565–569. doi:10.1097/00002480-200209000-00021

    Article  PubMed  Google Scholar 

  2. DeOreo PB (1997) Hemodialysis patient-assessed functional health status predicts continued survival, hospitalization, and dialysis-attendance compliance. Am J Kidney Dis 30:204–212. doi:10.1016/S0272-6386(97)90053-6

    Article  CAS  PubMed  Google Scholar 

  3. Merkus MP, Jager KJ, Dekker FW et al (1999) Physical symptoms and quality of life in patients on chronic dialysis: results of The Netherlands cooperative study on adequacy of dialysis (NECOSAD). Nephrol Dial Transplant 14:1163–1170. doi:10.1093/ndt/14.5.1163

    Article  CAS  PubMed  Google Scholar 

  4. McHutchison JG, Ware JE Jr, Bayliss MS et al (2001) Hepatitis interventional therapy group the effects of interferon alpha-2b in combination with ribavirin on health related quality of life and work productivity. J Hepatol 34:140–147. doi:10.1016/S0168-8278(00)00026-X

    Article  CAS  PubMed  Google Scholar 

  5. Spiegel BMR, Younossi ZM, Hays RD et al (2005) Impact of hepatitis C on health related quality of life: a systematic review and quantitative assessment. Hepatology 41:790–800. doi:10.1002/hep.20659

    Article  PubMed  Google Scholar 

  6. Kwan JW, Cronkite RC, Yiu A et al (2008) The impact of chronic hepatitis C and co-morbid illnesses on health-related quality of life. Qual Life Res 17:715–724. doi:10.1007/s11136-008-9344-3

    Article  PubMed  Google Scholar 

  7. Beck AT, Ward CH, Mendelson M et al (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:561–571

    CAS  PubMed  Google Scholar 

  8. Micozkadioglu H, Micozkadioglu I, Zumrutdal A et al (2006) Relationship between depressive affect and malnutrition-inflammation complex syndrome in haemodialysis patients. Nephrology (Carlton) 11:502–505

    Article  CAS  Google Scholar 

  9. Koo JR, Yoon JW, Kim SG et al (2003) Association of depression with malnutrition in chronic hemodialysis patients. Am J Kidney Dis 41:1037–1042. doi:10.1016/S0272-6386(03)00201-4

    Article  PubMed  Google Scholar 

  10. Savasir I, Sahin NH (1997) Assessment in cognitive behavioral therapy: frequently used scales. Turkish Society of Psychologists, Ankara

    Google Scholar 

  11. Ware JE Jr, Sherbourne CD (1984) Physicians’ attitudes in counseling patients about smoking. Med Care 22:360–365. doi:10.1097/00005650-198404000-00007

    Article  PubMed  Google Scholar 

  12. Koçyigit H, Aydemir Ö, Fişek G et al (1999) Kısa form 36 (kf-36)’nın Türkçe versiyonunun güvenilirliği ve geçerliligi. İlaç ve tedavi dergisi 12:102–106

    Google Scholar 

  13. Johansen KL, Painter P, Kent-Braun JA et al (2001) Validation of questionnaires to estimate physical activity and functioning in end-stage renal disease. Kidney Int 59:1121–1127. doi:10.1046/j.1523-1755.2001.0590031121.x

    Article  CAS  PubMed  Google Scholar 

  14. Spiegel BM, Younossi ZM, Hays RD et al (2005) Impact of hepatitis C on health related quality of life: a systematic review and quantitative assessment. Hepatology 41:790–800. doi:10.1002/hep.20659

    Article  PubMed  Google Scholar 

  15. Forton DM, Taylor-Robinson SD, Thomas HC (2003) Cerebral dysfunction in chronic hepatitis C infection. J Viral Hepat 10:81–86. doi:10.1046/j.1365-2893.2003.00416.x

    Article  CAS  PubMed  Google Scholar 

  16. Walters BA, Hays RD, Spritzer KL et al (2002) Health-related quality of life, depressive symptoms, anemia, and malnutrition at hemodialysis initiation. Am J Kidney Dis 40:1185–1194. doi:10.1053/ajkd.2002.36879

    Article  PubMed  Google Scholar 

  17. Turk S, Atalay H, Altintepe L et al (2006) Treatment with antidepressive drugs improved quality of life in chronic hemodialysis patients. Clin Nephrol 65:113–118

    CAS  PubMed  Google Scholar 

  18. Ferenci P, Lockwood A, Mullen K et al (2002) Hepatic encephalopathy–definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 35:716–721. doi:10.1053/jhep.2002.31250

    Article  PubMed  Google Scholar 

  19. Davis GL, Balart LA, Schiff ER et al (1994) Assessing health-related quality of life in chronic hepatitis C using the sickness impact profile. Clin Ther 16:334–343

    CAS  PubMed  Google Scholar 

  20. Carithers RL Jr, Sugano D, Bayliss M (1996) Health assessment for chronic HCV infection: results of quality of life. Dig Dis Sci 41:75S–80S. doi:10.1007/BF02087879

    Article  PubMed  Google Scholar 

  21. Foster GR, Goldin RD, Thomas HC (1998) Chronic hepatitis C virus infection causes a significant reduction in quality of life in the absence of cirrhosis. Hepatology 27:209–212. doi:10.1002/hep.510270132

    Article  CAS  PubMed  Google Scholar 

  22. Bayliss MS, Gandek B, Bungay KM et al (1998) A questionnaire to assess the generic and disease-specific health outcomes of patients with chronic hepatitis C. Qual Life Res 7:39–55. doi:10.1023/A:1008884805251

    Article  CAS  PubMed  Google Scholar 

  23. Fontana RJ, Moyer CA, Sonnad S et al (2001) Comorbidities and quality of life in patients with interferon-refractory chronic hepatitis C. Am J Gastroenterol 96:170–178. doi:10.1111/j.1572-0241.2001.03473.x

    Article  CAS  PubMed  Google Scholar 

  24. Rodger AJ, Jolley D, Thompson SC et al (1999) The impact of diagnosis of hepatitis C virus on quality of life. Hepatology 30:1299–1301

    Article  CAS  PubMed  Google Scholar 

  25. Córdoba J, Reyes J, Esteban JI et al (2003) Labeling may be an important cause of reduced quality of life in chronic hepatitis C. Am J Gastroenterol 98:226–227

    PubMed  Google Scholar 

  26. Kutner NG, Zhang R, Huang Y et al (2008) Patient-reported sleep difficulty and cognitive function during the first year of dialysis. Int Urol Nephrol 40:203–210. doi:10.1007/s11255-007-9188-8

    Article  PubMed  Google Scholar 

  27. Iliescu EA, Coo H, McMurray MH et al (2003) Quality of sleep and health-related quality of life in haemodialysis patients. Nephrol Dial Transplant 18:126–132. doi:10.1093/ndt/18.1.126

    Article  PubMed  Google Scholar 

  28. Elder SJ, Pisoni RL, Akizawa T et al (2008) Sleep quality predicts quality of life and mortality risk in haemodialysis patients: results from the dialysis outcomes and practice patterns study (DOPPS). Nephrol Dial Transplant 23:998–1004. doi:10.1093/ndt/gfm630

    Article  PubMed  Google Scholar 

  29. Acaray A, Pinar R (2005) Quality of life in Turkish haemodialysis patients. Int Urol Nephrol 37:595–602. doi:10.1007/s11255-005-0397-8

    Article  PubMed  Google Scholar 

  30. Vasilieva IA (2006) Quality of life in chronic hemodialysis patients in Russia. Hemodial Int 10:274–278

    Article  PubMed  Google Scholar 

  31. Kalantar-Zadeh K, Kopple JD, Block G et al (2001) Association among SF-36 quality of life measures and nutrition, hospitalization, and mortality in hemodialysis. J Am Soc Nephrol 12:2797–2806

    CAS  PubMed  Google Scholar 

  32. Morton AR, Meers C, Singer MA et al (1996) Quantity of dialysis: quality of life–what is the relationship? ASAIO J 42:M713–M717

    Article  CAS  PubMed  Google Scholar 

  33. Unruh M, Benz R, Greene T et al (2004) Effects of hemodialysis dose and membrane flux on health-related quality of life in the HEMO study. Kidney Int 66:355–366. doi:10.1111/j.1523-1755.2004.00738.x

    Article  PubMed  Google Scholar 

  34. Merkus MP, Jager KJ, Dekker FW et al (1997) Quality of life in patients on chronic dialysis: self-assessment 3 months after the start of treatment. The Necosad study group. Am J Kidney Dis 29:584–592. doi:10.1016/S0272-6386(97)90342-5

    Article  CAS  PubMed  Google Scholar 

  35. Mapes DL, Lopes AA, Satayathum S et al (2003) Health-related quality of life as a predictor of mortality and hospitalization: the dialysis outcomes and practice patterns study (DOPPS). Kidney Int 64:339–349. doi:10.1046/j.1523-1755.2003.00072.x

    Article  PubMed  Google Scholar 

  36. Fabrizi F, Martin P, Dixit V et al (2004) Meta-analysis: effect of hepatitis C virus infection on mortality in dialysis. Aliment Pharmacol Ther 20:1271–1277. doi:10.1111/j.1365-2036.2004.02290.x

    Article  CAS  PubMed  Google Scholar 

  37. Thomas HC, Török ME, Forton DM et al (1999) Possible mechanisms of action and reasons for failure of antiviral therapy in chronic hepatitis C. J Hepatol 31(Suppl 1):152–159. doi:10.1016/S0168-8278(99)80393-6

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nephrology, Baskent University Hospital, 3. Cadde 50. Sokak 9/8, 06500, Bahcelievler, Ankara, Turkey

    Baris Afsar, Rengin Elsurer, Siren Sezer & Nurhan F. Ozdemir

Authors
  1. Baris Afsar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rengin Elsurer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Siren Sezer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nurhan F. Ozdemir
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Baris Afsar.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Afsar, B., Elsurer, R., Sezer, S. et al. Quality of life in hemodialysis patients: hepatitis C virus infection makes sense. Int Urol Nephrol 41, 1011–1019 (2009). https://doi.org/10.1007/s11255-009-9576-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11255-009-9576-3

Keywords

Search

Navigation