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Is male fertility associated with type 2 diabetes mellitus?

International Urology and Nephrology volume 41, Article number: 777 (2009) Cite this article

Abstract

Objective

The aim of this study was to determine the prevalence of infertility in Qatari men with Diabetes Mellitus (T2DM) and to examine the association between T2DM and infertility.

Design

This is a cross-sectional study.

Setting

The survey was conducted at Primary Health Care Centers during a period from January 2008 to June 2008.

Subjects

The selected subjects for the study were Qatari men aged 25–60 years who were married for more than 1 year. A total of 1,165 men were approached and only 857 men gave consent, giving a response rate of 73.6%.

Methods

Face-to-face interviews were based on a questionnaire that included variables on socio-demographic characteristics, type of infertility in men, life style habits, type of environmental exposures, and common diseases found among infertile men. All studied men were recruited using cluster random sampling at 13 randomly selected primary health care centers at the Hamad Medical Corporation.

Results

The prevalence of infertility in Qatari T2DM men was 35.1%. The prevalence of primary infertility (16%) and secondary infertility (19.1%) was significantly higher in diabetic men (P = 0.003) as compared to non-diabetic men. Also, secondary infertility was higher than primary infertility in our studied Qatari diabetic men. Half of the diabetic infertile men were overweight (50.6%) and 29.1% of them were obese. The smoking habit was more common in diabetic infertile men (45.6%) than in diabetic fertile men (33.6%). Multivariate logistic regression analysis confirmed that age (P < 0.001), smoking habits (ex-smokers, P = 0.003 and current smokers, P = 0.001) and obesity (P < 0.001) were the significant major contributors for infertility in diabetic men. Obesity was the leading contributor for the infertility. Other co-morbid factors associated with infertility in diabetic men were hypertension, erectile dysfunction, and varicocele.

Conclusion

The present study findings revealed that there is a strong association between male infertility and Diabetes Mellitus. In Qatari diabetic men, male infertility is high and a significant public health problem in Qatar. The study results confirmed a strong association between T2DM and infertility in Qatari men.

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Acknowledgments

This work was funded by Qatar Diabetic Association and Qatar Foundation. The project was supported and approved by Ethical Review Committee at Hamad Medical Corporation, Project ID (7085/2007), Doha, the State of Qatar.

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Affiliations

  1. Department of Medical Statistics & Epidemiology, Hamad General Hospital, Hamad Medical Corporation, Weill Cornell Medical College, P.O. Box 3050, Doha, Qatar

    Abdulbari Bener

  2. Department of Evidence for Population Health Unit, School of Epidemiology and Health Sciences, University of Manchester, Manchester, UK

    Abdulbari Bener

  3. Department of Urology, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar

    Abdulla A. Al-Ansari

  4. Department of Endocrinology, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar

    Mahmoud Zirie

  5. Qatar Diabetic Associations and Qatar Foundation, Doha, Qatar

    Abdulla O. A. A. Al-Hamaq

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  1. Abdulbari Bener
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  2. Abdulla A. Al-Ansari
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  3. Mahmoud Zirie
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  4. Abdulla O. A. A. Al-Hamaq
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Correspondence to Abdulbari Bener.

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Bener, A., Al-Ansari, A.A., Zirie, M. et al. Is male fertility associated with type 2 diabetes mellitus?. Int Urol Nephrol 41, 777 (2009). https://doi.org/10.1007/s11255-009-9565-6

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Keywords

  • Prevalence
  • Male infertility
  • Risk factors
  • Diabetes
  • Hypertension
  • Erectile dysfunction
  • Qatar