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Clinical symptoms related to renal cell carcinoma are independent prognostic factors for intraoperative complications and overall survival

  • Urology - Original Paper
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Abstract

Objective

It is not yet elucidated whether the symptoms related to renal cell carcinoma have a strong effect on intraoperative complications or survival. We aimed to investigate this association in a cohort of renal cancer patients operated on between June 1997 and December 2004 at the Department of Urology, Semmelweis University School of Medicine.

Patients and methods

Among 363 consecutive patients with renal masses treated at our institution, only 200 (55.3%) were truly asymptomatic and completely incidental (group A). Among the 259 patients with incidentally detected tumors, 59 (16.1%) had symptoms that were probably related to the renal lesion according to a reviewed history (group B) and 104 patients (28.6%) presented for symptoms related to renal cell cancer (group C).

Results

Patients in group B had a higher risk for weight loss (P < 0.0001) and flank pain (P = 0.063), lower risk for symptoms related to distant metastases, while their outcome was not significantly different from group C. The collapsed group (B + C) had an increased risk for metastasis (P = 0.002), higher stage (P = 0.001), and intraoperative complications (P = 0.046) compared to group A according to a logistic regression. The presence of symptoms was significantly related to the overall survival using the Kaplan–Meier method (P < 0.0001).

Conclusions

Weight loss and flank pain were frequently neglected as a possible symptom of renal cancer by the patients. An easily accessible parameter (the presence of symptoms) was independently related to intraoperative complications and survival in renal cancer patients.

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Authors and Affiliations

  1. Department of Urology, Semmelweis University, Budapest, Hungary

    Attila Szendrői, Peter Riesz, Miklós Szűcs, Peter Nyírády, Attila Majoros & Imre Romics

  2. Department of Internal Medicine, Semmelweis University, Budapest, Hungary

    Ádám Tabák

  3. Department of Urology, State University of New York, Syracuse, NY, USA

    Gabriel Haas

Authors
  1. Attila Szendrői
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  2. Ádám Tabák
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  3. Peter Riesz
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  4. Miklós Szűcs
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  5. Peter Nyírády
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  6. Attila Majoros
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  7. Gabriel Haas
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  8. Imre Romics
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Correspondence to Attila Szendrői.

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Szendrői, A., Tabák, Á., Riesz, P. et al. Clinical symptoms related to renal cell carcinoma are independent prognostic factors for intraoperative complications and overall survival. Int Urol Nephrol 41, 835–842 (2009). https://doi.org/10.1007/s11255-009-9539-8

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  • DOI: https://doi.org/10.1007/s11255-009-9539-8

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