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Comparison of the prevalence of calcidiol insufficiency in predialysis and osteoporotic populations

  • Nephrology - Original Paper
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Abstract

Aim

Calcidiol insufficiency is highly prevalent in chronic kidney disease (CKD) and osteoporotic patients. We assessed and compared calcidiol levels in these two groups from the same geographical area to differentiate environmental factors from characteristics related to CKD.

Methods

We measured calcidiol levels in 160 predialysis (group 1) and 53 osteoporotic (group 2) patients from a single center. Calcidiol insufficiency was defined as a level between 37.5 and 75 nmol/l and calcidiol deficiency was defined as a level below 37.5 nmol/l.

Results

In group 1, mean glomerular filtration rate (GFR), calcidiol, and parathyroid hormone (PTH) levels were 18.3 ± 4.7 ml/min, 38.7 ± 15.1 nmol/l, and 21.9 ± 19.1 pmol/l. Calcidiol insufficiency and deficiency were present in 98.7% of patients. There was an inverse correlation between calcidiol and PTH levels (r = −0.25; P = 0.001). In group 2, mean GFR, calcidiol levels, and PTH levels were 68.6 ± 17.6 ml/min, 73.8 ± 27.1 nmol/l, and 4.23 ± 1.83 pmol/l, respectively. Calcidiol insufficiency and deficiency were present in 50.9% of patients. There was an inverse correlation between calcidiol and PTH levels (r =−0.44; P = 0.02).

Conclusion

In our predialysis population, calcidiol insufficiency and deficiency are present in almost every patient, being more common than previously reported. It is also more frequent than in a similar osteoporotic population, suggesting a cause unrelated to environmental factors. Interestingly, there is a significant inverse correlation between calcidiol and parathyroid levels in both populations. Further studies are needed to enable understanding of the mechanisms underlying calcidiol insufficiency.

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Acknowledgments

Preliminary results of this work were presented at the 2006 and 2007 American Society of Nephrology meetings and published in abstract form (J Am Soc Nephrol, 17: 699A; 2006 and J Am Soc Nephrol, 18: 530A; 2007). VP is a scholar of Fonds de la recherche en santé du Québec.

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Authors and Affiliations

  1. Service de néphrologie, Hôpital Maisonneuve-Rosemont, Université de Montréal, 5415 Blvd. de l′Assomption, Montreal, QC, Canada, H1T 2M4

    Josée Bouchard, Denis Ouimet, Michel Vallée, Jean-Philippe Lafrance, Martine Leblanc, Lyne Sénécal, Alain Bonnardeaux & Vincent Pichette

  2. Service de rhumatologie, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montreal, Canada

    Jean-Pierre Mathieu

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  1. Josée Bouchard
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  2. Denis Ouimet
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  3. Michel Vallée
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  4. Jean-Philippe Lafrance
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  5. Martine Leblanc
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  6. Lyne Sénécal
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  7. Alain Bonnardeaux
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  8. Jean-Pierre Mathieu
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  9. Vincent Pichette
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Correspondence to Vincent Pichette.

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Bouchard, J., Ouimet, D., Vallée, M. et al. Comparison of the prevalence of calcidiol insufficiency in predialysis and osteoporotic populations. Int Urol Nephrol 41, 983–988 (2009). https://doi.org/10.1007/s11255-008-9509-6

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  • DOI: https://doi.org/10.1007/s11255-008-9509-6

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