Abstract
Bilateral adrenal neoplasms are very rare. Studies have shown that most are metastatic tumors, and clinical presentation varies with tumor type. We retrospectively reviewed medical records of 18 cases of bilateral adrenal tumor in our hospital between 2002 and 2007. The etiology was pheochromocytoma in six, primary lymphoma in four, nonfunctioning cortical adenoma in four, metastatic tumors in two, primary aldosteronism in one, and Cushing syndrome in one. Patients with lymphoma had largest average tumor size. Our findings suggest that pheochromocytoma, primary lymphoma, and nonfunctioning cortical adenoma are common causes of bilateral adrenal tumor.
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Mundada OP, Aron M, Sivaramakrishna B et al (2003) Bilateral adrenal metastases from a primary hepatocellular carcinoma. Int Urol Nephrol 35:303–305. doi:10.1023/B:UROL.0000022911.80669.71
Imai T, Kikumori T, Shibata A et al (2003) Laparoscopic adrenalectomy for incidentaloma and bilateral adrenal disease. Asian J Surg 26(2):64–70
Salvatore JR, Ross RS (1999) Primary bilateral adrenal lymphoma. Leuk Lymphoma 34:111–117
Safi S, Kassmaoui H, Hassikou H et al (2007) Primary non-Hodgkin’s lymphoma of the adrenals. A case report. Ann Endocrinol (Paris) 68:208–211. doi:10.1016/j.ando.2007.02.008
Kumar R, Xiu Y, Mavi A et al (2005) FDG-PET imaging in primary bilateral adrenal lymphoma: a case report and review of the literature. Clin Nucl Med 30(4):222–230. doi:10.1097/01.rlu.0000155983.46815.1c
Pimentel M, Johnston JB, Allan DR et al (1997) Primary adrenal lymphoma associated with adrenal insufficiency: a distinct clinical entity. Leuk Lymphoma 24:363–367
Gaboardi F, Carbone M, Bozzola A et al (1991) Adrenal incidentalomas: what is the role of fine needle biopsy? Int Urol Nephrol 23(3):197–207. doi:10.1007/BF02550412
Porcaro AB, Novella G, Ficarra V et al (2003) Incidental adrenal pheochromocytoma. Report on 5 operated patients and update of the literature. Arch Ital Urol Androl 75(4):217–225
Frymoyer PA, Anderson GH Jr, Blair DC (1986) Hemoptysis as a presenting symptom of pheochromocytoma. J Clin Hypertens 2(1):65–67
Kimura Y, Ozawa H, Igarashi M et al (2005) A pheochromocytoma causing limited coagulopathy with hemoptysis. Tokai J Exp Clin Med 30(1):35–39
Akoglu S, Ucan ES, Celik G et al (2005) Endobronchial metastases from extrathoracic malignancies. Clin Exp Metastasis 22(7):587–591. doi:10.1007/s10585-005-5787-x
Bourvis N, Fartoukh M, Christin-Maitre S et al (2006) Intra-alveolar hemorrhage revealing pheochromocytoma. Rev Pneumol Clin 62(1):43–48. doi:10.1016/S0761-8417(06)75413-X
Lino S, Nagashima N, Akiba H et al (1975) Hemoptysis and palpitation (with hypertension): pheochromocytoma. Nippon Rinsho 918–919:1394–1395
Colas JL (1965) Paroxysmal hypertension with haemoptysis due to a retroperitoneal paraganglioma. East Afr Med J 42(10):535–540
Sharma KC (1962) Symptomatology of phaeochromocytoma. Br J Clin Pract 16:513–514
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Zhou, J., Ye, D., Wu, M. et al. Bilateral adrenal tumor: causes and clinical features in eighteen cases. Int Urol Nephrol 41, 547–551 (2009). https://doi.org/10.1007/s11255-008-9484-y
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DOI: https://doi.org/10.1007/s11255-008-9484-y