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Prevalence of benign prostatic hyperplasia in a population-based study in Iranian men 40 years old or older

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Abstract

Epidemiology of benign prostatic hyperplasia (BPH) is incompletely understood. The following study was done to estimate the prevalence of BPH according to obstructive and irritative symptoms of prostate obstruction determined by uroflowmetry and prostate size. In a cross-sectional study a total of 8,466 men aged 40 or older were interviewed by 74 general practitioners and answered the International Prostate Symptom Score (I-PSS) questionnaire. The subjects were randomly identified from 30 counties of Iran. They were invited to have a digital rectal examination (DRE), serum total prostate-specific antigen (tPSA) assay, abdominal ultrasonography to measure prostate size and measurement of maximum urinary flow rate (Qmax). Data on medical history, toxic habits, and current use of medications were obtained. Of the men interviewed, the prevalence of BPH, defined as I-PSS greater than 7, maximum flow less than 15 ml/s and prostate size greater than 30 gm, was 23.8%. The prevalence increased with age, from 1.2% in men 40–49 to 36% in those >70 years (tested for trend, P = 0.001). A positive association was found between BPH and body mass index (BMI) (P = 0.04), height (P = 0.03), diabetes mellitus (P = 0.04), increased total energy intake (P = 0.02), age-adjusted levels of total PSA (P = 0.02), heart disease (P = 0.03), and marital status (P = 0.01). The prevalence of BPH is relatively high in Iran. The provided bothersome due to BPH did not correlate to symptom severity and should be considered independently in clinical decision-making.

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Acknowledgments

Many physicians, coordinators, project managers, secretaries, and data reviewers assisted in this study. I would like to thank all of them. The collection of data was made possible by the whole-hearted collaboration of the 74 general practitioners. Many thanks are due to for the nationwide financial support of the Iranian people. Certainly without this financial support, performing this study would have not been possible. Mrs. Nayyer Shafiei reviewed the medical records, Dr. Alireza Khoshdel provided preliminary analysis of these data, and Saba Safarinejad assisted in the preparation of the manuscript. The interpretation and reporting of these data are the responsibility of the author and in no way should be seen as an official policy or interpretation of the Iranian government.

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  1. Urology and Nephrology Research center, Shaheed Beheshti University of Medical Sciences, P.O. Box 19395-1849, Tehran, Iran

    Mohammad Reza Safarinejad

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  1. Mohammad Reza Safarinejad
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Correspondence to Mohammad Reza Safarinejad.

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Safarinejad, M.R. Prevalence of benign prostatic hyperplasia in a population-based study in Iranian men 40 years old or older. Int Urol Nephrol 40, 921–931 (2008). https://doi.org/10.1007/s11255-008-9338-7

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  • DOI: https://doi.org/10.1007/s11255-008-9338-7

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