Skip to main content

Advertisement

Log in

Membranoproliferative glomerulonephritis associated with pseudoxanthoma elasticum

  • Case report
  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Pseudoxanthoma elasticum (PXE) is a multiorgan disorder affecting mainly the skin, the eyes, and the cardiovascular system. A 51-year-old woman was admitted to our clinic complaining of weakness and swelling of her legs for the past two years. She had a proteinuria of 7.29 g/24 h. Renal biopsy was performed, and the histological diagnosis was membranoproliferative glomerulonephritis. Four weeks later, she was admitted to the hospital due to pain in her left hand and necrosis in the fourth and fifth fingertips of the left hand. A skin biopsy was performed from the forearm and was reported as PXE. Herein, we present a case of membranoproliferative glomerulonephritis accompanying PXE.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Hu X, Plomp AS, van Soest S et al (2003) Pseudoxanthoma Elasticum: A Clinical, Histopathological and Molecular Update. Surv Ophthalmol 48:424–438

    Article  PubMed  Google Scholar 

  2. Vanakker OM, Voet D, Petrovic M et al (2006) Visceral and testicular calcifications as part of the phenotype in pseudoxanthoma elasticum: ultrasound findings in Belgian patients and healthy carriers. Br J Radiol 79:221–225

    Article  PubMed  CAS  Google Scholar 

  3. Crespi G, Derchi LE, Saffioti S (1992) Sonographic detection of renal changes in pseudoxanthoma elasticum. Urol Radiol 13:223–225

    PubMed  CAS  Google Scholar 

  4. Goodman RM, Smith EW, Paton D et al (1963) Pseudoxanthoma elasticum: A clinical and histopathological study. Medicine 42:297–304

    Article  PubMed  CAS  Google Scholar 

  5. Lebwohl M, Neldner K, Pope FM et al (1994) Classification of pseudoxanthoma elasticum: report of a consensus conference. J Am Acad Dermatol 30:103–107

    PubMed  CAS  Google Scholar 

  6. Bergen AA, Plomp AS, Schuurman EJ et al (2000) Mutations in ABCC6 cause pseudoxanthoma elasticum. Nat Genet 25:228–231

    Article  PubMed  CAS  Google Scholar 

  7. Le Saux O, Urban Z, Tschuch C et al (2000) Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum. Nat Genet 25:223–227

    Article  PubMed  CAS  Google Scholar 

  8. Matsuzaki Y, Nakano A, Jiang QJ et al (2005) Tissue-specific expression of the ABCC6 gene. J Invest Dermatol. 125:900–905

    PubMed  CAS  Google Scholar 

  9. Kool M, van der Linden M, de Haas M et al (1999) Expression of human MRP, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells. Cancer Res 59:175–182

    PubMed  CAS  Google Scholar 

  10. Suarez MJ, Garcia JB, Orense M et al (1991) Sonographic aspects of pseudoxanthoma elasticum. Pediatr Radiol 21:538–539

    Article  PubMed  CAS  Google Scholar 

  11. Domjan JM, Dewbury KC (1996) Case report: multiple highly reflective foci in the renal parenchyma are not specific for pseudoxanthoma elasticum. Br J Radiol 69:871–872

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Faruk Turgut.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Altay, M., Turgut, F., Karakurt, F. et al. Membranoproliferative glomerulonephritis associated with pseudoxanthoma elasticum. Int Urol Nephrol 40, 1099–1101 (2008). https://doi.org/10.1007/s11255-007-9290-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11255-007-9290-y

Keywords

Navigation