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Immunoglobulin A nephropathy complicating ulcerative colitis

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Abstract

Ulcerative colitis is rarely associated with immunoglobulin A nephropathy (IgAN). The development of IgA nephropathy complicates further the clinical course of patients with ulcerative colitis. A 72-year old man with a 30-year history of ulcerative colitis requiring colectomy and modest renal insufficiency secondary to complications of nephrolithiasis and renal artery stenosis developed glomerular hematuria, proteinuria and progressive renal failure. Percutaneous kidney biopsy revealed IgAN with extensive glomerular and interstitial sclerotic changes. After resection of a chronically infected ileo-rectal pouch, renal function improved, while hematuria and proteinuria gradually disappeared without specific treatment of the IgAN. The manifestations of IgAN complicating ulcerative colitis can be improved with effective treatment of the bowel disease even when there are extensive sclerotic changes in the kidneys.

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Authors and Affiliations

  1. Renal Section, New Mexico Veterans Affairs Health Care System (VAHCS), Albuquerque, New Mexico, USA

    Aideloje Onime, Karen S. Servilla & Antonios H. Tzamaloukas

  2. Department of Medicine, University of New Mexico (UNM) School of Medicine, Albuquerque, New Mexico, USA

    Aideloje Onime, Yijuan Sun, Robert B. Parsons, Karen S. Servilla & Antonios H. Tzamaloukas

  3. Department of Medicine, Faculty of Medical Sciences, University of Jos, Jos, Plateau State, Nigeria

    Emmanuel I. Agaba

  4. General Medicine Section, New Mexico VAHCS, Albuquerque, New Mexico, USA

    Robert B. Parsons

  5. Pathology Section, New Mexico VAHCS, Albuquerque, New Mexico, USA

    Larry W. Massie

  6. Department of Pathology, UNM School of Medicine, Albuquerque, New Mexico, USA

    Larry W. Massie

  7. Nephrology Division, Department of Medicine, Jos University Teaching Hospital, P.M.B 2076, Jos, Plateau State, Nigeria

    Emmanuel I. Agaba

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  1. Aideloje Onime
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  2. Emmanuel I. Agaba
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  3. Yijuan Sun
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Correspondence to Emmanuel I. Agaba.

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Onime, A., Agaba, E.I., Sun, Y. et al. Immunoglobulin A nephropathy complicating ulcerative colitis. Int Urol Nephrol 38, 349–353 (2006). https://doi.org/10.1007/s11255-006-0061-y

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  • DOI: https://doi.org/10.1007/s11255-006-0061-y

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