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Schistosoma-induced amyloidosis in hamsters is gender-dependent

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Abstract

Background A high serum level of female protein (FP), found to be a constituent of Syrian hamster amyloid was associated with enhanced amyloidosis. In this work, we studied the sex-limited factors in the induction of amyloidosis in Syrian hamsters infected with either Schistosoma mansoni or S. hematobium cercariae. Methods Hamsters were infected with different species of schistosome cercariae and sacrificed after different time periods of infection. Kidney and liver specimens were processed in paraffin, stained with Congo-red and examined by ordinary light and polarized light microscopy.Results Statistical analysis showed a significant difference in intensity of kidney and liver amyloid deposits (P<0.002 & <0.007 respectively) between females and male hamsters with extensive deposits in the former. Amyloid deposits were correlated significantly to the duration of infection (P<0.001) than the load of worm recovered.Conclusion From this study, we conclude that, in hamster model, Schistosoma-induced amyloidosis is enhanced in females than male hamsters. This may be due to the high serum level of FP that is normally detected in females. As an experimental model for schistosomal nephropathy, we recommend to use male hamsters instead of females to minimize the effect of amyloid deposits, which may mask other pathological changes associated with schistosomal infection.

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References

  1. Barsoum RS (2003) Schistosomiasis and the kidney. Semin Nephrol 23(1):34–41

    Article  PubMed  Google Scholar 

  2. Barsoum RS, Bassily S, Soliman MM, Ramzy MF, Milad M, Hassaballa AM (1979) Renal amyloidosis and schistosomiasis. Trans R Soc Trop Med Hyg 73:367–374

    Article  PubMed  CAS  Google Scholar 

  3. Sobh MA, Moustafa FE, Ramzy RM, Saad M, Deelder AM, Ghoneim MA (1990a) Schistosoma mansoni nephropathy in Syrian golden hamsters: Effect of dose and duration of infection. Nephron 59:121–130

    Google Scholar 

  4. Sobh MA, Moustafa FE, Ramzy RM, Deelder AM, Ghoneim (1990b) S. haematobium induced glomerular disease: an experimental study in the golden hamster. Nephron 57:216–222

    Article  Google Scholar 

  5. Glenner GG (1981) The bases of the staining of myloid fibers: their physicochemical nature and the mechanism of their dye-substrate interaction. Prog Histochem Cytochem 13(3):1–37

    PubMed  CAS  Google Scholar 

  6. Glenner GG (1986) Reactive systemic amyloidosis in cystic fibrosis and other disorders associated with chronic inflammation. Arch Pathol Lab Med 110(10):873–874

    PubMed  CAS  Google Scholar 

  7. Dealwis C, Wall J (2004) Towards understanding the structure-function relationship of human amyloid disease. Curr Drug Targets 5(2):159–571

    Article  PubMed  CAS  Google Scholar 

  8. Cathcart ES, Elliott-Bryant R (1999) Diet, amyliod enhancing factors (AEF) and amyloidosis: a hypothesis. Amyloid 6(2):107–113

    PubMed  CAS  Google Scholar 

  9. Husby G, Brandtzaeg P, Mellbye OJ, Thompson K, Sletten K, Aarset H (2002) Protein deposition diseases: when structurally altered proteins assemble out of place. With special emphasis on monoclonal immunoglobulin deposition disease causing erosive polyarthropathy. Scand J Rheumatol 31(2):60–65

    Article  PubMed  Google Scholar 

  10. Coe JE, Margossian SS, Slayter HS, Sogn JA (1981) Hamster female protein. A new Pentraxin structurally and functionally similar to C-reactive protein and amyloid P component. J Exp Med 153(4):977–991

    Article  PubMed  CAS  Google Scholar 

  11. Coe JE, Ross MJ (1985) Hamster female protein, a sex-limited pentraxin, is a constituent of Syrian hamster amyloid. J Clin Invest 76(1):66–74

    Article  PubMed  CAS  Google Scholar 

  12. Coe JE, Ross MJ (1990) Amyloidosis and female protein in the Syrian hamster. Concurrent regulation by sex hormones. J Exp Med 171(4):1257–1267

    Article  PubMed  CAS  Google Scholar 

  13. Van Marck EAE, Jacob W, Deelder AM, Gigase PLJ (1978) Spontaneous glomerular basement membrane changes in the golden Syrian hamster (Mesocricetus auratus): a light and electron microscopic study. Lab Animal 12:207–211

    Google Scholar 

  14. Deelder AM, Kornelis D, Van Marck EAE, Eveleigh PC, Egmond JC (1980) Schistosoma mansoni: characterization of two circulating ploysaccharide antigens and the immunological response to these antigens in mouse, hamsters and human infections. Exp Parasitol 50:16–32

    Article  PubMed  CAS  Google Scholar 

  15. Hillyer GV, Lewert RM (1974) Studies on renal pathology in hamsters infected with S. mansoni and S. japonicum. Am J Trop Med Hyg 23:404–411

    PubMed  CAS  Google Scholar 

  16. Cheever AW (1986) A quantitative post-mortem study of schistosomiasis mansoni in man. Am J Trop Med Hyg 17:38–42

    Google Scholar 

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Correspondence to Sahar Mohamed Hamed.

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Hamed, S.M., EL-Kenawy, A.EM., El-kott, A.F. et al. Schistosoma-induced amyloidosis in hamsters is gender-dependent. Int Urol Nephrol 38, 707–712 (2006). https://doi.org/10.1007/s11255-006-0055-9

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  • DOI: https://doi.org/10.1007/s11255-006-0055-9

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