Abstract
Multiple myeloma is characterized by marrow plamacytsois, M spike in serum or urine electrophoresis and skeletal lytic lesions. The M spike may be absent in rare instances. We describe a case of myeloma cast nephropathy with acute renal failure who did not exhibit an M spike. λ-chain staining was documented on immunoperoxidase, suggesting paraprotein-related tubular damage.
Similar content being viewed by others
References
V Sakhuja V Jha S Varma et al. (2000) ArticleTitleRenal involvement in multiple myeloma: a 10-year study Ren Fail 22 465–277 Occurrence Handle10.1081/JDI-100100888 Occurrence Handle10901184
RA Kyle MA Gertz TE Witzig et al. (2003) ArticleTitleReview of 1027 patients with newly diagnosed multiple myeloma Mayo Clin Proc 78 21–33 Occurrence Handle12528874
DR Felix M Giralt MP. Giraldo (1987) ArticleTitleNonsecretory multiple myeloma Cancer 59 1847–1852 Occurrence Handle3828953
EF Osserman K. Takatsuki (1963) ArticleTitlePlasma cell myeloma: Gammaglobulin synthesis and structure Med Baltimore 42 357–84
H Matsuzaki M Yoshida Y. Akahoshi (1991) ArticleTitlePseudo-nonsecretory multiple myeloma with light chain deposition disease Acta Hematol 85 164–168
IA Abdalla IA. Tabbara (2002) ArticleTitleNonsecretory multiple myeloma South Med J 95 761–764 Occurrence Handle12144086
H Avet-Loiseau R Garand L Lode et al. (2003) ArticleTitleIntergroupe Francophone du Myelome. Translocation t(11;14) (q13;q32) is the hallmark of IgM, IgE, and nonsecretory multiple myeloma variants Blood 101 1570–1571 Occurrence Handle10.1182/blood-2002-08-2436 Occurrence Handle12393502
MV Joyner JP Cassuto P. Dujardin (1979) ArticleTitleNonexceretory multiple myeloma Brit J Hematol 43 559–566
JR Tate D Gill R Cobcroft PE. Hickman (2003) ArticleTitlePractical considerations for the measurement of free light chains in serum Clin Chem 49 1252–1257 Occurrence Handle10.1373/49.8.1252 Occurrence Handle12881439
P Paueksakon MP Revelo RG Horn et al. (2003) ArticleTitleMonoclonal gammopathy: significance and possible causality in renal disease Am J Kidney Dis 42 87–95 Occurrence Handle10.1016/S0272-6386(03)00412-8 Occurrence Handle12830460
H Matsuzaki M Yoshida Y Akahoshi et al. (1991) ArticleTitlePseudo-nonsecretory multiple myeloma with light chain deposition disease Acta Haematol 85 164–168 Occurrence Handle1904181
G Lugassy A Ducach C Yossefi J. Michal (1993) ArticleTitleUnusual case of amyloidosis complicating nonsecretory multiple myeloma Am J Hematol 43 332–333 Occurrence Handle8372828
K Solling J Solling NO Jacobsen OF. Thomsen (1980) ArticleTitleNonsecretory myeloma associated with nodular glomerulosclerosis Acta Med Scand 207 137–143 Occurrence Handle6768224
T Yamagishi Y Higashi M Okamoto et al. (1985) ArticleTitleCase report of nonsecretory multiple myeloma with acute onset of renal failure and nodular glomerulosclerosis Nippon Jinzo Gakkai Shi 27 851–857 Occurrence Handle4079118
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kumar, S.K., Sohal, P.M., Kohli, H.S. et al. Acute Renal Failure due to Cast Nephropathy in Nonsecretory Myeloma: A Case Report and Review of the Literature. Int Urol Nephrol 37, 351–353 (2005). https://doi.org/10.1007/s11255-004-2362-3
Issue Date:
DOI: https://doi.org/10.1007/s11255-004-2362-3