Abstract
Background: The effect of erythropoietin (EPO) therapy on the serum level of IGF-I among hemodialysis patients is debated. The aim of this study is to study the effect of EPO on the erythropoiesis and the change of serum level of IGF-I among adequately hemodialyzed patients. Patients and methods: Forty patients (25 males and 15 females) who had an adequate level of both hemodialysis and nutrition were randomly allocated into two equal groups. Besides parenteral iron, the first group of patients received a conventional EPO dose regimen of 2000 U subcutaneously (SC) thrice weekly, the second group of patients remained on parenteral iron and ranked as a control group. The patients were subjected to thorough laboratory investigations. IGF-I concentration was measured before and at the end of the study. Results. Both groups were comparable in their demographic, laboratory, dialysis level, and nutritional status. There was no statistical differences in hemoglobin, hematocrit %, iron store indices and serum level of IGF-I at the study entry. We found a significant rise of both hemoglobin and hematocrit as well as IGF-I serum level in the EPO group at the end of the study in comparison to their values at the starting points in comparison to the control group (P< 0.001). Conclusion: Erythropoietin therapy enhances erythropoiesis and modulates the serum concentration of IGF-I.
Similar content being viewed by others
References
AJ. Collins (2003) ArticleTitleAnemia management prior to dialysis: Cardiovascular and cost benefit observations Nephrol Dial Transplant 18 IssueIDS2 2–6 Occurrence Handle10.1093/ndt/gfg1032
AJ Collins S Li W St Peter J Ebben T Roberts JZ Ma W. Manning (2001) ArticleTitleDeath, hospitalization, and economic associations among incident hemodialysis patients with hematocrit values of 36%–39% J Am Soc Nephrol 12 2465–2473 Occurrence Handle11675424
A Besarab CM Reyes J. Hornberger (2002) ArticleTitleMeta-analysis of subcutaneous versus intravenous EPO in maintenance treatment of anemia in hemodialysis patients Am J Kidney Dis 40 IssueID3 439–446 Occurrence Handle10.1053/ajkd.2002.34881 Occurrence Handle12200793
JL Jones DR. Clemmons (1995) ArticleTitleInsulin-like growth factors and their binding proteins: Biological actions Endocr Rev 16 IssueID1 3–34 Occurrence Handle10.1210/er.16.1.3 Occurrence Handle7758431
S Miyagawa M Kobayashi N Konishi T Sato et al. (2000) ArticleTitleInsulin and insulin-like growth factor I support the proliferation of erythroid progenitor cells in bone marrow through the sharing of receptors Br J Haematol 109 IssueID3 555–562 Occurrence Handle10.1046/j.1365-2141.2000.02047.x Occurrence Handle10886204
JT Daugirdas TA. Depner (1994) ArticleTitleA nomogram approach to hemodialysis urea modeling Am J Kidney Dis 23 IssueID1 33–40 Occurrence Handle8285195
WH Daughaday P. Rotwein (1989) ArticleTitleInsulin-like growth factor-I and II. Peptides, messenger ribonucleic acid and gene structure, serum and tissue concentrations Endocrine Rev 10 IssueID1 68–91
P Urena A Bonnardeaux KU Eckardt A Kurtz et al. (1992) ArticleTitleInsulin-like growth factor I: A modulator of erythropoiesis in uraemic patients? Nephrol Dial Transplant 7 IssueID1 40–44 Occurrence Handle1316579
S. Merchav (1998) ArticleTitleThe haematopoietic effects of growth hormone and insulin-like growth factor I J Pediatr Endocrinol Metab 11 IssueID6 677–685 Occurrence Handle9829220
G Ramirez PA Bittle H Sanders HA Rabb et al. (1994) ArticleTitleThe effects of corticotropin and growth hormone releasing hormones on their respective secretory axes in chronic hemodialysis patients before and after correction of anemia with recombinant human erythropoietin J Clin Endocrinol Metab 78 IssueID1 63–69 Occurrence Handle10.1210/jc.78.1.63 Occurrence Handle8288716
MJ Fernandez-Reyes F Alvarez-Ude R Sanchez C Mon P Iglesias JJ Diez A. Vazquez (2002) ArticleTitleInflammation and malnutrition as predictors of mortality in patients on hemodialysis J Nephrol 15 IssueID2 136–143 Occurrence Handle12018629
N Besbas F Ozaltin T Coskun Ozalp et al. (2003) ArticleTitleRelationship of leptin and insulin-like growth factor I to nutritional status in hemodialyzed children Pediatr Nephrol. 18 IssueID12 1255–1259 Occurrence Handle10.1007/s00467-003-1264-4 Occurrence Handle14586683
M Sohmiya Y. Kato (2001) ArticleTitleEffect of long-term administration of recombinant human growth hormone (rhGH) on plasma erythropoietin (EPO) and hemoglobin levels in anemic patients with adult GH deficiency Clin Endocrinol (Oxf) 55 IssueID6 749–754 Occurrence Handle10.1046/j.1365-2265.2001.01417.x
LY Shih JY Huang CT. Lee (1999) ArticleTitleInsulin-like growth factor I plays a role in regulating erythropoiesis in patients with end-stage renal disease and erythrocytosis J Am Soc Nephrol. 10 IssueID2 315–322 Occurrence Handle10.1159/000017161 Occurrence Handle10215331
J Malyszko S Wolczynski E Zbroch S Brzosko et al. (2002) ArticleTitleInsulin-like growth factor system components in relation to erythropoietin therapy and bone metabolism in dialyzed patients and kidney transplant recipients Nephron 90 IssueID3 282–289 Occurrence Handle10.1159/000049064 Occurrence Handle11867949
JF Navarro C Mora M Macia J. Garcia (2002) ArticleTitleRandomized prospective comparison between EPO and androgens in CAPD patients Kidney Int 61 IssueID4 1537–1544 Occurrence Handle10.1046/j.1523-1755.2002.00271.x Occurrence Handle11918762
HE Carlson ML Graber MC Gelato JM. Hershman (1995) ArticleTitleEndocrine effects of erythropoietin Int J Artif Organs 18 IssueID6 309–314 Occurrence Handle8593965
M Matsumura H Nomura I Koni H. Mabuchi (1997) ArticleTitleAngiotensin-converting enzyme inhibitors are associated with the need for increased recombinant human erythropoietin maintenance doses in hemodialysis patients Nephron 77 IssueID2 164–168 Occurrence Handle9346382
S Albitar R Genin M Fen-Chong MO Serveaux B. Bourgeon (1998) ArticleTitleHigh dose enalapril impairs the response to erythropoietin treatment in haemodialysis patients Nephrol Dial Transplant 13 IssueID5 1206–1210 Occurrence Handle10.1093/ndt/13.5.1206 Occurrence Handle9623555
LF Morrone S Di Paolo F Logoluso A Schena et al. (1997) ArticleTitleInterference of angiotensin converting enzyme inhibitors on erythropoiesis in kidney transplant recipients: role of growth factors and cytokines Transplantation 64 IssueID6 913–918 Occurrence Handle10.1097/00007890-199709270-00021 Occurrence Handle9326420
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Sheashaa, H.A., Khalil, A., Aarman, M.M.E. et al. Correction of Hemodialysis Anemia is Associated with Significant Increase in Serum Concentration of IGF-I in Patients Treated with Erythropoietin: A Randomized Controlled Study. Int Urol Nephrol 37, 153–158 (2005). https://doi.org/10.1007/s11255-004-2360-5
Issue Date:
DOI: https://doi.org/10.1007/s11255-004-2360-5