Abstract
The use of herbal medicine to treat various diseases is becoming increasingly important as an alternative therapy. Numerous plants have been traditionally used for different purposes, including antiparasitic in humans and animals. Diseases caused by gastrointestinal parasites in ruminants, especially by the nematode Haemonchus contortus, cause large economic losses to the producers, whether by complications of the diseases or the cost of treatment. The main way of handling nematodiasis is by administering anthelmintic drugs, but their excessive use has the disadvantage of causing drug resistance; therefore, an alternative is the use of herbal medicine for this purpose. Mesquite (Prosopis spp.) has been used in Mexico to treat gastrointestinal diseases attributed to helminths. The present study aimed to characterize the rheological properties of mesquite flour using the SeDeM Expert System to determine its suitability for tablet production by direct compression. Direct compression technology facilitates the tableting process by reducing manufacturing costs. The results of the present study indicate that mesquite flour can be processed by direct compression. The latter could allow the manufacturing of economic tablets to treat infections by H. contortus in ruminants.
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Data availability
The datasets analyzed during the current study are available from the corresponding author upon request.
References
Al-Zoubi, N., Gharaibeh, S. F., Aljaberi, A., & Nikolakakis, I. (2021). Spray Drying for Direct Compression of Pharmaceuticals. Processes, 9(2), 267. https://doi.org/10.3390/pr9020267
Andrade-Montemayor, H., Córdova-Torres, A., García-Gasca, T., Kawas J., 2011. Alternative foods for small ruminants in semiarid zones, the case of Mesquite (Prosopis spp.) and Nopal (Opuntia spp.). Small Ruminant Research. 98(1–3): 83–92. https://doi.org/10.1016/j.smallrumres.2011.03.023
Besier, R.B., Kahn, L.P., Sargison, N.D., Van Wyk, J.A., 2016. Diagnosis, Treatment and Management of Haemonchus contortus in Small Ruminants. Advances in Parasitology. 93: 181–238. https://doi.org/10.1016/bs.apar.2016.02.024
Cerón-Ortiz, A.N., Vidal-Gómez, A.Y. and Ángeles Monroy, M.A., (2015). Impacto del estado de madurez de la vaina de mezquite (Prosopis laevigata) en su composición fisicoquímica posterior a su transformación en polvo. Revista Congreso Nacional de Ingeniería y Tecnologías para el Desarrollo Sustentable. 1, pp. 1-7. http://conainte.itsoeh.edu.mx/revista/docs/VOL1_01-07.pdf
Crouter, A. Briens, L., 2013. The Effect of Moisture on the Flowability of Pharmaceutical Excipients. An Official Journal of the American Association of Pharmaceutical Scientists, 15(1), 65–74. https://doi.org/10.1208/s12249-013-0036-0
De Jesús-Gabino, A.F., Mendoza, P., Salinas-Sánchez, D.O., López-Arellano, M.E., Liébano-Hernández, E., Hernández-Velázquez, V.M., Valladares-Cisneros, G., 2009. Anthelmintic effects of Prosopis laevigata-hexanic extract against Haemonchus contortus in artificially infected gerbils (Meriones unguiculatus). Journal of Helminthology. 84(1): 71-75. https://doi.org/10.1017/s0022149x09990332
De Melo-Cavalcante, A.M., De Melo, A.M., Da Silva, A.V.F., Da Silva-Neto, G.J., Barbi, R.C.T., Ikeda, M., Silva, G.B., Steel, C.J., Silva, O.S.D., 2022. Mesquite (Prosopis juliflora) grain flour: new ingredient with bioactive, nutritional, and physical-chemical properties for food applications. Future Foods. 5: 100114. https://doi.org/10.1016/j.fufo.2022.100114
Díaz-Batalla, L., Hernández-Uribe, J.P., Román-Gutiérrez, A.D., Cariño-Cortés, R., Castro-Rosas, J., Téllez-Jurado, A., Gómez-Aldapa, C.A., 2018. Chemical and nutritional characterization of raw and thermal-treated flours of Mesquite (Prosopis laevigata) pods and their residual brans. CyTA - Journal of Food. 16(1): 444–451. https://doi.org/10.1080/19476337.2017.1418433
Farmacopea de los Estados Unidos Mexicanos. (FEUM), 2018. Secretaría de Salud, Comisión permanente de la. Farmacopea de los Estados Unidos Mexicanos. 12 ed. México.
García, S.M.J, Santos, B.D, 2001. Formas sólidas orales. En Vila-Jato (Ed.), Tecnología Farmacéutica. Vol. II. Editorial Síntesis. Madrid. 87-105 pp.
Ghori, M. U. & Conway, B., (2016) “Powder Compaction: Compression Properties of Cellulose Ethers”, British Journal of Pharmacy 1(1). https://doi.org/10.5920/bjpharm.2016.09
Gonzales-Barron, U., Dijkshoorn, R., Maloncy, M., Finimundy, T., Calhelha, R.C., Pereira, C., Stojković, D., Soković, M., Ferreira, I.C.F.R., Barros, L., Cadavez, V., 2020. Nutritive and Bioactive Properties of Mesquite (Prosopis pallida) Flour and Its Technological Performance in Breadmaking. Foods. 9(5): 597. https://doi.org/10.3390/foods9050597
Instituto Nacional de Estadística y Geografía e Informática. (INEGI). (s.f.). Cuéntame de México. Hidalgo. Recuperado 26 de Abril de 2023. https://cuentame.inegi.org.mx/monografias/informacion/hgo/territorio/clima.aspx?tema=me&e=13
López-Aroche, U., Salinas-Sánchez, D.O., Mendoza De Gives, P., López-Arellano, M.E., Liébano-Hernández, E., Valladares-Cisneros, G., Arias-Ataide, D.M., Hernández-Velázquez, V., 2008. In vitro nematicidal effects of medicinal plants from the Sierra de Huautla, Biosphere Reserve, Morelos, Mexico against Haemonchus contortus infective larvae. Journal of Helminthology. 82(1): 25–31. https://doi.org/10.1017/s0022149x07873627
Moya, M., Escudero, V., 2015. Las plantas medicinales en el control de nemátodos gastrointestinales en cabras: potencial de las plantas que crecen en la región de Coquimbo, Chile. Revista Brasileira de Plantas Medicinais. 17(3): 480-494. https://doi.org/10.1590/1983-084X/13_103
Munguía-Xóchihua, J.A., Valenzuela-Medrano, J.C., Leyva-Corona, J.C., Morales-Pablos, M.I., Figueroa-Castillo, 2013. Potencial del orégano como alternativa natural para controlar Haemonchus contortus en ovinos de pelo. evista Latinoamericana de Recursos Naturales. 9(1): 150–154. https://revista.itson.edu.mx/index.php/rlrn/article/view/222
Muñoz-Guzmán, M.A., Sánchez-González, V.H., Revilla, V.A., Abd-Elghany, H.A., Cuenca-Verde,. C., Cuéllar-Ordaz, J.A., Alba-Hurtado, F., 2016. Efecto de la hemoncosis experimental sobre las concentraciones séricas de sodio, potasio y cobre en dos razas ovinas. Quehacer Científico en Chiapas. 11(2): 68–75. https://www.dgip.unach.mx/images/pdf-REVISTA-QUEHACERCIENTIFICO/2016-jul-dic/Efecto_de_la_hemoncosis_experimental.pdf
Pinilla, J.C., Flórez, P., Sierra, M., Morales, E., Sierra, R., Vásquez, M.C., Tobon, J.C., Sánchez, A., Ortiz D., 2018. Prevalencia del parasitismo gastrointestinal en bovinos del departamento Cesar Colombia. Revista de Investigaciones Veterinarias del Perú. 29(1): 278–287. https://doi.org/10.15381/rivep.v29i1.14202
Reyes López, L. G. (2017). Caracterización de polvos (harinas) de mezquite (Prosopis laevigata) para aplicaciones alimentarias. Tesis de maestría (no publicada). Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional Unidad Oaxaca, Instituto Politécnico Nacional. México.
Reyes-Guerrero, D. E., Olmedo-Juárez, A., Mendoza-de Gives, P., 2021. Control y prevención de nematodosis en pequeños rumiantes: antecedentes, retos y perspectivas en México. Revista Mexicana de Ciencias Pecuarias. 12:186–204. https://doi.org/10.22319/rmcp.v12s3.5840
Rojas, J., Aristizabal, J., & Henao, M. (2013). Screening of several excipients for direct compression of tablets: A new perspective based on functional properties. DOAJ (DOAJ: Directory of Open Access Journals).
Salim, I., Olowosulu, A.K., Abdulsamad, A., Gwarzo, M.S., Khalid, G.M., Ahmad, N.T., Eichie, F.E., Kurfi, F.S., 2021. Application of SeDeM Expert System in the development of novel directly compressible co-processed excipients via co-processing. Future Journal of Pharmaceutical Sciences. 7(135):1-12. https://doi.org/10.1186/s43094-021-00253-z
Sandler, N., Reiche, K., Heinämäki, J., Yliruusi, J., 2010. Effect of Moisture on Powder Flow Properties of Theophylline. Pharmaceutics. 2(3): 275–290. https://doi.org/10.3390/pharmaceutics2030275
Scholtz, J.C., Steenekamp, J.H., Hamman, J.H., Tiedt, L.R., 2017. The SeDeM Expert Diagram System: Its performance and predictability in direct compressible formulations containing novel excipients and different types of active ingredients. Powder Technology. 312: 222–236. https://doi.org/10.1016/j.powtec.2017.02.019
Sipos, E., Oltean, A.R., Szabó, Z.I., Rédai, E.M., Nagy G.D., 2017. Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets. Acta Pharmaceutica. 67(2): 237–246. https://doi.org/10.1515/acph-2017-0017
Suñe, J.M., Roiģ Carreras, M., García, R.F., Montoya, E.G., Lozano, P.P., Aģuilar, J.E., Carmona, M.M., Ticó-Grau, J.R., 2013. SeDeM Diagram: an expert system for preformation, characterization and optimization of tablets obtained by direct compression. Formulation Tools for Pharmaceutical Development. 109–135. https://doi.org/10.1533/9781908818508.109
Suñe-Negre, J. M., Roig, M., Fuster, R., Hernández, C., Ruhí, R., García-Montoya, E., Pérez-Lozano, P., Miñarro, M., Ticó., J. R., 2014. New classification of directly compressible (DC) excipients in function of the SeDeM Diagram Expert System. International Journal of Pharmaceutics. 470: 15–27. https://doi.org/10.1016/j.ijpharm.2014.04.068
Wan, S., Yang, R., Zhang, H., Li, X., Gu, M., Guan, T., Ren, J., Sun, H., Dai C., 2019. Application of the SeDeM Expert System in Studies for Direct Compression Suitability on Mixture of Rhodiola Extract and an Excipient. An Official Journal of the American Association of Pharmaceutical Scientists. 20(3): 105. https://doi.org/10.1208/s12249-019-1320-4
Zhang, Y., Li, Y., Wu, F., Hong, Y., Shen, L., Lin, X., Feng, Y., 2021. Texture and surface feature-mediated striking improvements on multiple direct compaction properties of Zingiberis Rhizoma extracted powder by coprocessing with nano-silica. International Journal of Pharmaceutics. 603: 120703. https://doi.org/10.1016/j.ijpharm.2021.120703
Acknowledgements
The authors thank Dr. Juan Carlos Ángeles Hernández from the Autonomous University of the State of Hidalgo for providing the mesquite used in the development of this work, and Verónica Rodríguez thank CONAHCYT for the postdoctoral stay 2022 (1).
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Aline Cristina Cazares-Solis: methodology, validation, investigation, and writing—original draft.
Verónica Rodríguez-Guerrero: conceptualization, formal analysis, supervision, and writing—reviewing and editing.
Oswaldo Castañeda Hernández: formal analysis, supervision, and writing—reviewing and editing.
Luz María Melgoza Contreras: resources, supervision, project administration, and writing—reviewing and editing.
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Cazares-Solis, A.C., Rodríguez-Guerrero, V., Castañeda Hernández, O. et al. Application of the SeDeM system for the preparation of antiparasitic tablets from mesquite flour for use in sheep. Trop Anim Health Prod 56, 81 (2024). https://doi.org/10.1007/s11250-024-03926-y
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DOI: https://doi.org/10.1007/s11250-024-03926-y