Skip to main content
SpringerLink
Log in

Additional intracervical prostaglandin reduces induction to calving time in buffaloes affected with incomplete cervical dilatation post-uterine detorsion

  • Technical Note
  • Published:
Tropical Animal Health and Production Aims and scope Submit manuscript

Abstract

Conventional induction protocol (CIP) of calving in buffaloes employs the intramuscular (IM) administration of dexamethasone (40 mg) and cloprostenol sodium (500 μg). If there is no progression in terms of cervical dilatation, then a second dose of cloprostenol sodium (500 μg) is administered intramuscularly. This protocol possesses certain demerits: (1) a wide range of response time intervals, and (2) increased risk of fetal membrane retention. Considering the cervix as a caudal continuation of the myometrium with its own contractile potential, and the limitations of CIP, we developed intracervical (IC) drug administration route in buffaloes. The proposed technique was evaluated for its use in a total of 22 cases of incomplete cervical dilatation in uterine torsion-affected buffaloes (IC-14 and IM-8). In addition to CIP, the IC group received an intracervical injection of cloprostenol sodium (500 μg) at the start of the experiment whereas the IM group received an extra intramuscular dose of cloprostenol sodium (500 μg) either after 24 h or when no progression in cervical dilatation is noticed. Surprisingly, the average response time during the experiment in the IC group was 5.8 h shorter (p < 0.000) than in the IM group (IC-5.7 ± 0.17 h vs. IM-11.9 ± 0.74 h). The duration from calving to fetal membrane expulsion (IC-12.8 ± 0.60 h vs. IM-17.5 ± 1.40 h; p < 0.002) and incidence of retention of fetal membrane were also less in the IC group (57.1% vs. 87.5%). The proposed intracervical drug administration potentiates cervical dilatation and can be regarded as a safe, effective, and feasible technique for attaining reliable results.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Data availability

Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

References

  • Azawi, O.I., Naoman, U.T., Al-Kass, Z.M., Lazim, E.H. and Fathi, N.G., 2011. Misoprostol treatment of dystocia due to incomplete dilatation of the cervix in a cow: a case report. Iraqi Journal of Veterinary Science, 25 (2), 97–98.

    Article  Google Scholar 

  • Bo, G.A., Fernandez, M., Barth, A.D. and Mapletoft, R.J, 1992. Reduced incidence of retained placenta with induction of parturition in the cow. Theriogenology, 38,45-61.

    Article  CAS  PubMed  Google Scholar 

  • Breeveld-Dwarkasing, V.N.A., Struijk, P.C., Lotgering, F.K., Eijskoot, F., Kindahl, H., van der Weijden, G.C., and Taverne, M.A.M., 2005. Cervical dilatation related to uterine electromyographic activity and endocrinological changes during prostaglandin f2α-induced parturition in cows, Biology of Reproduction, 68, 536–542.

    Article  Google Scholar 

  • Chaudhari, R.K., Sutaria, T.V., Patel, A.C. and Chaudhari, C.F., 2023. Doppler indices of uterine arteries and mRNA transcripts of hormone receptors in cervix vis-à-vis dilatation therapy in buffaloes affected with incomplete cervical dilatation associated with uterine torsion. Animal Reproduction Science, 248, 107183.

    Article  CAS  PubMed  Google Scholar 

  • Chaudhari, R.K., Sutaria, T.V., Chaudhari, C.F., Nakhashi, H.C. and Suthar, B.N., 2019. A clinical study on incomplete dilation of cervix associated with uterine torsion in Mehsana buffaloes. In 7th Annual convention of Society for Veterinary Science and Biotechnology (SVSBT) national seminar on Biotechnological advances for improving animal health and productivity organized by College of Veterinary Science & Animal Husbandry. Navsari Agricultural University, Navsari on 5–6, December 2019. Pp.

  • Das, G.K., Dutt, R., Deori, S., Jaglan, P., Kumar, P., Gokuldas, P.P., 2008. Incomplete cervical dilatation causing dystocia in a buffalo. Indian Journal of Animal Reproduction, 17 (2), 41-43.

    Google Scholar 

  • de Carvalho, N.A.T., Soares, J.G., Kahwage, P.R. and Garcia, A. Anatomy of the Reproductive Tract of the Female and Male Buffaloes. In: Bubaline Theriogenology. International Veterinary Information Service. 2014. https://ainfo.cnptia.embrapa.br/digital/bitstream/item/139389/1/CARVALHO-SOARES-KAHWAGE-e-GARCIA-2014-Anatomy-of-the-Reproductive-Tract-of-the-Female-and-Male-Buffaloes.pdf. Accessed on 25 Nov 2023

  • Gahlot, S.C., Kumaresan, A., Kumar, S., Yadav, S., Saraf, K.K., Karan, P. and Verma, K., 2017. Incomplete cervical dilatation in animals–an update. International Journal of Science Environment and Technology, 6 (2), 1036-1048.

    Google Scholar 

  • Hartmann, D., Bollwein, H., Honnens, A., Niemann, H., Rath, D., and Pfarrer, C., 2013. Protracted induction of parturition enhances placental maturation, but does not influence incidence of placental retention in cows. Theriogenology, 80(3), 185-192.

    Article  CAS  PubMed  Google Scholar 

  • Hixon, J. E., and Hansel, W., 1974. Evidence for preferential transfer of prostaglandin F2α to the ovarian artery following intrauterine administration in cattle. Biology of reproduction, 11(5), 543-552.

    Article  CAS  PubMed  Google Scholar 

  • Honparkhe, M., Ghuman, S. P. S., Kumar, A., Gupta, K., Sood, N. K., Ahuja, C. S., 2009. Cervical massage with sodium carboxy methyl cellulose for achieving complete cervical dilatation in successfully detorted uterine torsion affected buffaloes, Indian Journal of Animal Sciences, 79 (1) 26-29.

    Google Scholar 

  • Hussein, H.A., 2013. Validation of color Doppler ultrasonography for evaluating the uterine blood flow and perfusion during late normal pregnancy and uterine torsion in buffaloes. Theriogenology, 79 (7), 1045-1053.

    Article  PubMed  Google Scholar 

  • Jeengar, K., Purohit, G.N., Mehta, J.S., Choudhary, V., Ruhil, S. and Tripathi, A., 2015. Prevalence of uterine torsion and its management in buffaloes. Theriogenology Insight, 5 (3), 203-211.

    Google Scholar 

  • Kumar, B., Kumar, A., Kharayat, N.S., Bisla, A., Rashid, M., Ahmad, Sheikh, P. and Ramoorthy, M., 2018. Uterine torsion associated with incomplete cervical dilatation and subsequent fetal maldisposition: A case report. Research Journal Chemical Environment and Science, 6 (5), 72–74.

    Google Scholar 

  • Ledgert, W.L., Ellwood, D.A. and Taylor, M.J., 1983. Cervical softening in late pregnant sheep by infusion of prostaglandin E-2 into a cervical artery. Reproduction, 69(2), 511-515.

    Article  Google Scholar 

  • Lewing, F. J., Proulx, J., and Mapletoft, R. J., 1985. Induction of Parturition in the Cow using Cloprostenol and Dexamethasone in Combination, Can Vet J, 26 (10), 317-22.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Noakes, D.E., Parkinson, T.J. and England, G.C.W., 2019. Veterinary Reproduction and Obstetrics, tenth edition.,. Elsevier, Edinburgh, Scotland, pp. 118–119.

    Google Scholar 

  • Oppegaard, K.S., 2009. Misoprostol’s preoperative cervical ripening effect. Ph.D.thesis, University of Oslo.

    Google Scholar 

  • Rabidas, S.K., Gofur, M.R., Juyena, N.S., Alam, M.G.S., 2015. Controlled Induction of Parturition in the Dairy Buffaloes: An Approach of Success of Buffalo Breeding Farm in Bangladesh. Asian J. Anim. Sci. 9, 241-247.

    Article  CAS  Google Scholar 

  • Sahu, M., Gupta, T., Yadav, D.K. and Singh, C., 2019. Treatment of simultaneous occurrence of uterine torsion and incomplete cervical dilatation in Surti buffalo. Journal of Entomology and Zoology Studies, 7(2), 89-90.

    Google Scholar 

  • Shoyaib, A.A., Archie, S. R., and Karamyan, V. T., 2020. Intraperitoneal route of drug administration: should it be used in experimental animal studies? Pharm Res, 37, 1-12.

    Article  Google Scholar 

  • Singh, N., Gandotra, V.K., Ghuman, S.P.S., Pathak, D. and Honparkhe, M., 2021. Cervical histomorphology of successfully detorted uterine torsion affected buffaloes subjected to intracervical hyaluronidase or PgE (1) treatment. Indian Journal of Animal Sciences, 91 (5), 376-381

    Article  CAS  Google Scholar 

  • van Engelen, E., Taverne, M. A. M., Everts, M. E., van der Weijden, G. C., Doornenbal, A., Breeveld-Dwarkasing, V. N. A., 2007. EMG activity of the muscular and stromal layer of the cervix in relation to EMG activity of the myometrium and cervical dilatation in PGF2α induced parturition in the cow, Theriogenology, 67, 1158–1167.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Veterinary Clinical Complex, DGCN College of Veterinary and Animal Sciences, CSK Himachal Pradesh Krishi Vishvavidyalaya, Palampur, H.P., India

    Ankit Ahuja

  2. Department of Veterinary Gynaecology and Obstetrics, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India

    Mrigank Honparkhe, Ajeet Kumar & Amarjeet Bisla

  3. Department of Veterinary Gynaecology and Obstetrics, DGCN College of Veterinary and Animal Sciences, CSK Himachal Pradesh Krishi Vishvavidyalaya, Palampur, H.P., India

    Pankaj Sood

Authors
  1. Ankit Ahuja
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mrigank Honparkhe
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ajeet Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Amarjeet Bisla
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Pankaj Sood
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Ankit Ahuja, Mrigank Honparkhe, and Amarjeet Bisla. The first draft of the manuscript was written by Ankit Ahuja and all authors commented on previous versions of the manuscript. Pankaj Sood did the final proof reading of the manuscript.

Corresponding author

Correspondence to Ankit Ahuja.

Ethics declarations

Ethical approval

All the procedures carried out during the experiment were performed adhering to the ethical standards drafted by the Institutional Ethical Committee.

Competing interests

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ahuja, A., Honparkhe, M., Kumar, A. et al. Additional intracervical prostaglandin reduces induction to calving time in buffaloes affected with incomplete cervical dilatation post-uterine detorsion. Trop Anim Health Prod 56, 16 (2024). https://doi.org/10.1007/s11250-023-03866-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s11250-023-03866-z

Keywords

Search

Navigation