Abstract
Cottonseed cake contains gossypol, a potentially toxic compound that, when consumed by sheep, can affect reproduction, the immune system, and the liver. Changes in hematologic and serum biochemical parameters were monitored for 63 days in 12 Santa Inês ewes, six of which received ration containing 400 g kg−1 of cottonseed cake. Blood samples were collected at the start of the experiment and weekly thereafter for hematologic assessment and determination of serum urea, creatinine, total protein, and albumin concentrations and for measurement of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyl transferase activities. No clinical signs of toxicity were observed. Evaluation of the erythron showed that sheep consuming cottonseed cake had an increased packed cell volume (p < 0.05) and increased erythrocyte counts and hemoglobin concentrations (p < 0.05) in the leukogram and serum biochemistry panel. In conclusion, consumption of 400 g kg−1 cottonseed cake by sheep for 63 days may induce changes in the erythron but no consistent changes in serum biochemical parameters, indicating no damage to the liver or kidneys.
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Acknowledgments
This work was supported by a grant from the Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq (#474432/2012-2) and the Fundação de Amparo à Pesquisa do Estado de Minas Gerais—FAPEMIG (#BPD-00378-14).
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The experimental protocol used in this study was approved by the Institutional Animal Care and Use Committee at the Universidade Federal Rural do Semi-Árido/UFERSA (process 23091.003174/2014-61).
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Câmara, A.C.L., do Vale, A.M., Mattoso, C.R.S. et al. Effects of gossypol from cottonseed cake on the blood profile in sheep. Trop Anim Health Prod 48, 1037–1042 (2016). https://doi.org/10.1007/s11250-016-1039-0
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DOI: https://doi.org/10.1007/s11250-016-1039-0