Compositional equivalence of event IND-ØØ412-7 to non-transgenic wheat

  • Francisco Ayala
  • Griselda V. Fedrigo
  • Moises Burachik
  • Patricia V. MirandaEmail author
Original Paper


Wheat is the most widely grown cereal grain, occupying a significant portion of the total cultivated land. As drought is the major environmental stressor affecting crop production, yield maintenance under water deficit conditions appears as a highly desirable phenotype for crop improvement. The HaHB4 (Helianthus annuus homeobox 4) gene from sunflower encodes for a transcription factor involved in tolerance to environmental stress. The introduction of HaHB4 in wheat led to the development of event IND-ØØ412-7 (HB4® wheat), which displayed higher yield in production environments of low productivity potential. Compositional analysis of IND-ØØ412-7 wheat, including 41 nutrients and 2 anti-nutrients for grain and 10 nutrients in forage, was performed. Results of these studies indicated that IND-ØØ412-7 is compositionally equivalent to non-transgenic wheat.


Wheat IND-ØØ412-7 Food safety evaluation Compositional analysis Transgenic wheat 



The authors would like to thank the Bioceres/INDEAR Agronomy group for the generation and preparation of the samples used in this study, and Melacrom laboratory for conducting the analytical procedures. We thank Dr. Raquel Chan for reviewing this manuscript and making very useful suggestions. This work was partially supported by Ministerio de Ciencia, Tecnología e Innovación Productiva, Agencia Nacional de Promoción Científica y Tecnológica, ANR 800 249/10.


This work was partially supported by Ministerio de Ciencia, Tecnología e Innovación Productiva, Agencia Nacional de Promoción Científica y Tecnológica, ANR 800 249/10.

Compliance with ethical standards

Conflict of interest

All the authors are affiliated to INDEAR, the R&D area of Bioceres, working for Trigall Genetics in the development of the transgenic event involved in this study.

Supplementary material

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Supplementary material 1 (PDF 190 kb)
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Supplementary material 2 (PDF 166 kb)
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Supplementary material 4 (PDF 162 kb)
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Supplementary material 5 (PDF 173 kb)


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Instituto de Agrobiotecnologia Rosario (INDEAR)RosarioArgentina
  2. 2.Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)Buenos AiresArgentina

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