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Potential subchronic food safety of the stacked trait transgenic maize GH5112E-117C in Sprague-Dawley rats

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Abstract

The food safety of stacked trait genetically modified (GM) maize GH5112E-117C containing insect-resistance gene Cry1Ah and glyphosate-resistant gene G2-aroA was evaluated in comparison to non-GM Hi-II maize fed to Sprague-Dawley rats during a 90-day subchronic feeding study. Three different dietary concentrations (12.5, 25 and 50 %, w/w) of the GM maize were used or its corresponding non-GM maize. No biologically significant differences in the animals’ clinical signs, body weights, food consumption, hematology, clinical chemistry, organ weights and histopathology were found between the stacked trait GM maize groups, and the non-GM maize groups. The results of the 90-day subchronic feeding study demonstrated that the stacked trait GM maize GH5112E-117C is as safe as the conventional non-GM maize Hi-II.

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Abbreviations

USDA:

United States Department of Agriculture

GM:

Genetically modified

Bt:

Bacillus thuringiensis

SPF:

Specific pathogen free

GMOs:

Genetically modified organisms

OECD:

Organization for Economic Cooperation and Development

EU:

European Union

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Acknowledgments

This work was supported by Genetically Modified Organisms Breeding Major Projects of PR China Grant 2014ZX0801103B. The authors also give the best appreciation to the Beijing Origin Seed Technology Inc. (Beijing, China) for providing the GM maize GH5112E-117C and the near-isogenic non-GM maize Hi-II.

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Correspondence to Xiaohong Mei.

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Han, S., Zou, S., He, X. et al. Potential subchronic food safety of the stacked trait transgenic maize GH5112E-117C in Sprague-Dawley rats. Transgenic Res 25, 453–463 (2016). https://doi.org/10.1007/s11248-016-9944-6

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  • DOI: https://doi.org/10.1007/s11248-016-9944-6

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