Abstract
The food safety of stacked trait genetically modified (GM) maize GH5112E-117C containing insect-resistance gene Cry1Ah and glyphosate-resistant gene G2-aroA was evaluated in comparison to non-GM Hi-II maize fed to Sprague-Dawley rats during a 90-day subchronic feeding study. Three different dietary concentrations (12.5, 25 and 50 %, w/w) of the GM maize were used or its corresponding non-GM maize. No biologically significant differences in the animals’ clinical signs, body weights, food consumption, hematology, clinical chemistry, organ weights and histopathology were found between the stacked trait GM maize groups, and the non-GM maize groups. The results of the 90-day subchronic feeding study demonstrated that the stacked trait GM maize GH5112E-117C is as safe as the conventional non-GM maize Hi-II.
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Abbreviations
- USDA:
-
United States Department of Agriculture
- GM:
-
Genetically modified
- Bt:
-
Bacillus thuringiensis
- SPF:
-
Specific pathogen free
- GMOs:
-
Genetically modified organisms
- OECD:
-
Organization for Economic Cooperation and Development
- EU:
-
European Union
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Acknowledgments
This work was supported by Genetically Modified Organisms Breeding Major Projects of PR China Grant 2014ZX0801103B. The authors also give the best appreciation to the Beijing Origin Seed Technology Inc. (Beijing, China) for providing the GM maize GH5112E-117C and the near-isogenic non-GM maize Hi-II.
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Han, S., Zou, S., He, X. et al. Potential subchronic food safety of the stacked trait transgenic maize GH5112E-117C in Sprague-Dawley rats. Transgenic Res 25, 453–463 (2016). https://doi.org/10.1007/s11248-016-9944-6
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DOI: https://doi.org/10.1007/s11248-016-9944-6