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Analysing patent landscapes in plant biotechnology and new plant breeding techniques

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Abstract

This article aims to inform the reader of the importance of searching patent landscapes in plant biotechnology and the use of basic tools to perform a patent search. The recommendations for a patent search strategy are illustrated with the specific example of zinc finger nuclease technology for genetic engineering in plants. Within this scope, we provide a general introduction to searching using two online and free-access patent databases esp@cenet and PatentScope. The essential features of the two databases, and their functionality is described, together with short descriptions to enable the reader to understand patents, searching, their content, patent families, and their territorial scope. We mostly stress the value of patent searching for mining scientific, rather than legal information. Search methods through the use of keywords and patent codes are elucidated together with suggestions about how to search with or combine codes with keywords and we also comment on limitations of each method. We stress the importance of patent literature to complement more mainstream scientific literature, and the relative complexities and difficulties in searching patents compared to the latter. A parallel online resource where we describe detailed search exercises is available through reference for those intending further exploration. In essence this is aimed at a novice patent searcher who may want to examine accessory patent literature to complement knowledge gained from mainstream journal resources.

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References

  • Beetham PR, Kipp PB, Sawycky XL, Arntzen CJ, May GD (1999) A tool for functional plant genomics: chimeric RNA/DNA oligonucleotides cause in vivo gene-specific mutations. Proc Natl Acad Sci USA 96:8774–8778

    Article  PubMed  CAS  Google Scholar 

  • Bibikova M, Golic M, Golic KG, Carroll D (2002) Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases. Genetics 161:1169–1175

    PubMed  CAS  Google Scholar 

  • Bogdanove AJ, Voytas DF (2011) TAL effectors: customizable proteins for DNA targeting. Science 333:1843–1846

    Article  PubMed  CAS  Google Scholar 

  • Curtin SJ, Zhang F, Sander JD, Haun WJ, Starker C, Baltes NJ, Reyon D, Dahlborg EJ, Goodwin MJ, Coffman AP, Dobbs D, Joung JK, Voytas DF, Stupar RM (2011) Targeted mutagenesis of duplicated genes in soybean with zinc-finger nucleases. Plant Physiol 156:466–473

    Article  PubMed  CAS  Google Scholar 

  • D’Halluin K, Vanderstraeten C, Stals E, Cornelissen M, Ruiter R (2008) Homologous recombination: a basis for targeted genome optimization in crop species such as maize. Plant Biotechnol J 6:93–102

    PubMed  Google Scholar 

  • Dunwell JM (2005) Review: intellectual property aspects of plant transformation. Plant Biotechnol J 3:371–384

    Article  PubMed  CAS  Google Scholar 

  • Durai S, Mani M, Kandavelou K, Wu J, Porteus MH, Chandrasegaran S (2005) Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells. Nucleic Acids Res 33:5978–5990

    Article  PubMed  CAS  Google Scholar 

  • Ghafele R, DiGiammarino P, Gilbert B (2011) Capitalising on innovation by crowdsourcing patent application review. CIPA J 40:296–298

    Google Scholar 

  • Kowalski SP, Ebora RV, Kryder RD, Potter RH (2002) Transgenic crops, biotechnology and ownership rights: what scientists need to know. Plant J 31:407–421

    Article  PubMed  CAS  Google Scholar 

  • Lusser M, Parisi C, Plan D, Rodriguez-Cerezo E (2012) Deployment of new biotechnologies in plant breeding. Nat Biotech 30:231–239

    Article  CAS  Google Scholar 

  • Parisi C, Rodriguez-Cerezo E, Thangaraj H (2012) Patent search strategies in plant biotechnology. http://dx.doi.org/10.1038/protex.2012.021. Protocol Exchange

  • Petolino J, Worden A, Curlee K, Connell J, Strange Moynahan T, Larsen C, Russell S (2010) Zinc finger nuclease-mediated transgene deletion. Plant Mol Biol 73:617–628

    Article  PubMed  CAS  Google Scholar 

  • Porteus MH, Carroll D (2005) Gene targeting using zinc finger nucleases. Nat Biotechnol 23:967–973

    Article  PubMed  CAS  Google Scholar 

  • Puchta H, Dujon B, Hohn B (1993) Homologous recombination in plant cells is enhanced by in vivo induction of double strand breaks into DNA by a site-specific endonuclease. Nucleic Acids Res 21:5034–5040

    Article  PubMed  CAS  Google Scholar 

  • Shukla VK, Doyon Y, Miller JC, DeKelver RC, Moehle EA, Worden SE, Mitchell JC, Arnold NL, Gopalan S, Meng X, Choi VM, Rock JM, Wu Y-Y, Katibah GE, Zhifang G, McCaskill D, Simpson MA, Blakeslee B, Greenwalt SA, Butler HJ, Hinkley SJ, Zhang L, Rebar EJ, Gregory PD, Urnov FD (2009) Precise genome modification in the crop species Zea mays using zinc-finger nucleases. Nature 459:437–441

    Article  PubMed  CAS  Google Scholar 

  • Thangaraj H (2007) Information from patent office could aid replication. Nature 447:638

    Article  PubMed  CAS  Google Scholar 

  • Thangaraj H, van Dolleweerd CJ, McGowan EG, Ma JKC (2009) Dynamics of global disclosure through patent and journal publications for biopharmaceutical products. Nat Biotech 27:614–618

    Article  CAS  Google Scholar 

  • UPOV (1991) Act of 1991. International Convention for the Protection of New Varieties of Plants of December 2, 1961 as Revised at Geneva on November 10, 1972, on October 23, 1978, and on March 19, 1991. International Union for the Protection of New varieties of plants

  • Urnov FD, Rebar EJ, Holmes MC, Zhang HS, Gregory PD (2010) Genome editing with engineered zinc finger nucleases. Nat Rev Genet 11:636–646

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

Harry Thangaraj is supported by EU FP7 Grant 241839. We thank Pascal Drake for his useful comments when preparing the manuscript. The views expressed are purely those of the authors and may not in any circumstances be regarded as stating an official position of the European Commission.

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Correspondence to Claudia Parisi.

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Parisi, C., Rodríguez-Cerezo, E. & Thangaraj, H. Analysing patent landscapes in plant biotechnology and new plant breeding techniques. Transgenic Res 22, 15–29 (2013). https://doi.org/10.1007/s11248-012-9641-z

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  • DOI: https://doi.org/10.1007/s11248-012-9641-z

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