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Advances in Metal-Catalyzed Denitrogenative Pathways for N-Heterocycle Synthesis

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Abstract

For more than a century, cutting-edge research in organic chemistry has been the discovery of novel, powerful synthetic procedures to create very significant N-heterocyclic scaffolds. Nitrogen-containing heterocyclic scaffolds owing to their extensive abundance in natural products and bioactive compounds has gathered a growing attention in both academical and industrial sectors in pursuit of development of highly efficient clinical targets and drug candidates. Given the significance of nitrogen-rich compounds in contemporary science, significant efforts have been conducted over the past few decades investigating effective techniques for synthesis of N-heterocycles. Due to its intrinsic flexibility and extensive range of applications, catalytic denitrogenative reaction employing transition metal has differentiated itself as a cornerstone among numerous initiatives. In the present article we have outlined the most recent breakthroughs in metal-catalyzed denitrogenative reactions, for proactive synthesis N-heterocycles.

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  1. Deepak Ranjan Mishra, Bhabani Shankar Panda and Arundhati Barik have contributed equally to this work.

Authors and Affiliations

  1. Department of Chemistry, Ravenshaw University, Cuttack, 753003, India

    Deepak Ranjan Mishra, Bhabani Shankar Panda & Nilima Priyadarsini Mishra

  2. Department of Basic Sciences, IITM, IES University, Bhopal, MP, 462044, India

    Subhendu Chakroborty

  3. Department of Physics, Indra Ganesan College of Engineering, Affiliated to Anna University, Trichy, India

    P. Lalitha

  4. CIPET: Institute of Petrochemicals Technology [IPT], Bhubaneswar, Odisha, India

    Arundhati Barik

  5. Kabi Samrat Upendra Bhanja (KSUB) College, Bhanjanagar, Ganjam, Odisha, India

    Amiya Ranjan Panda

  6. Department of Life Sciences & Biological Sciences, IES University, Bhopal, India

    Jitendra Malviya, Kiran Khatarkar & Madhubanti Mukopadhyay

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  1. Deepak Ranjan Mishra
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Mishra, D.R., Chakroborty, S., Lalitha, P. et al. Advances in Metal-Catalyzed Denitrogenative Pathways for N-Heterocycle Synthesis. Top Catal 67, 246–262 (2024). https://doi.org/10.1007/s11244-023-01880-x

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